TIMP3 Kit ELISA

N° du produit ABIN5510570

Détail du produit TIMP3 Kit ELISA

Antigène: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Épitope: AA 24-211

Reactivité: Cheval

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of horse equine TIMP-3

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: C24-P211

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Sequence similarities: Belongs to the protease inhibitor I35 (TIMP) family.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: TIMP3 (TIMP Metallopeptidase Inhibitor 3 (TIMP3))

Autre désignation: TIMP3 (TIMP3 Produits)

Synonymes: TIMP-3 Kit ELISA, TIMP3 Kit ELISA, timp3 Kit ELISA, HSMRK222 Kit ELISA, K222 Kit ELISA, K222TA2 Kit ELISA, SFD Kit ELISA, IMP-3 Kit ELISA, timp3-A Kit ELISA, Timp-3 Kit ELISA, metalloproteinase inhibitor 3 Kit ELISA, TIMP metallopeptidase inhibitor 3 Kit ELISA, Metalloproteinase inhibitor 3 Kit ELISA, TIMP metallopeptidase inhibitor 3 L homeolog Kit ELISA, tissue inhibitor of metalloproteinase 3 Kit ELISA, CpipJ_CPIJ003282 Kit ELISA, TIMP3 Kit ELISA, timp3 Kit ELISA, Timp3 Kit ELISA, timp3.L Kit ELISA

Sujet:

Protein Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.

Background: The tissue inhibitors of metalloproteinases(TIMPs) are natural inhibitors of the matrix metalloproteinases, a group of zinc-binding endopeptidases involved in the degradation of the extracellular matrix. The TIMP3 gene is expressed in many tissues, with highest expression in the placenta. TIMP3 encodes a potent angiogenesis inhibitor and is mutated in Sorsby fundus dystrophy, a macular degenerative disease with submacular choroidal neovascularization. TIMP3 gene is mapped to 22q12.1-q13.2. Mutations in TIMP3 cause the autosomal dominant disorder Sorsby's fundus dystrophy(SFD).

Synonyms: Metalloproteinase inhibitor 3,Protein MIG-5,Tissue inhibitor of metalloproteinases 3,TIMP-3,TIMP3,

Full Gene Name: Metalloproteinase inhibitor 3

Cellular Localisation: Secreted, extracellular space, extracellular matrix.

UniProt: P35625