GZMB Kit ELISA

N° du produit ABIN5510620

Détail du produit GZMB Kit ELISA

Antigène: GZMB (Granzyme B (GZMB))

Épitope: AA 21-247

Reactivité: Souris

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse Granzyme B

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO, Immunogen sequence: I21-S247

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: GZMB (Granzyme B (GZMB))

Autre désignation: Gzmb (GZMB Produits)

Synonymes: CCPI Kit ELISA, CGL-1 Kit ELISA, CGL1 Kit ELISA, CSP-B Kit ELISA, CSPB Kit ELISA, CTLA1 Kit ELISA, CTSGL1 Kit ELISA, HLP Kit ELISA, SECT Kit ELISA, granzyme B Kit ELISA, GZMB Kit ELISA

Sujet:

Protein Function: This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis (By similarity). .

Background: Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are thought to protect their host by inducing apoptosis of cells that bear on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Synonyms: Granzyme B(G,H),3.4.21.79,CTLA-1,Cytotoxic cell protease 1,CCP1,Fragmentin-2,Gzmb,Ctla-1, Ctla1,

Full Gene Name: Granzyme B(G,H)

Cellular Localisation: Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

UniProt: P04187

Pathways: Apoptose, Caspase Cascade in Apoptosis