MPL Kit ELISA

N° du produit ABIN5510636

Détail du produit MPL Kit ELISA

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Épitope: AA 26-482

Reactivité: Souris

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Mouse TPOR/MPL

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: Q26-W482

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))

Autre désignation: Mpl (MPL Produits)

Synonymes: C-MPL Kit ELISA, CD110 Kit ELISA, MPLV Kit ELISA, THCYT2 Kit ELISA, TPOR Kit ELISA, TPO-R Kit ELISA, c-mpl Kit ELISA, c-mpl-I Kit ELISA, c-mpl-II Kit ELISA, hlb219 Kit ELISA, MPL Kit ELISA, mpll Kit ELISA, tpor Kit ELISA, tpor.b Kit ELISA, MPL proto-oncogene, thrombopoietin receptor Kit ELISA, myeloproliferative leukemia virus oncogene Kit ELISA, MPL Kit ELISA, Mpl Kit ELISA, mpl Kit ELISA

Sujet:

Protein Function: Receptor for thrombopoietin. May represent a regulatory molecule specific for TPO-R-dependent immune responses.

Background: The thrombopoietin receptor (TPOR), also known as CD110, is a protein that in humans is encoded by the MPL (myeloproliferative leukemia virus) oncogene. The human MPL gene is mapped to chromosome 1p34. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated.

Synonyms: Thrombopoietin receptor,TPO-R,Myeloproliferative leukemia protein,Proto-oncogene c-Mpl,CD110,Mpl,Tpor,

Full Gene Name: Thrombopoietin receptor

Cellular Localisation: Cell membrane, Single-pass type I membrane protein . Golgi apparatus . Cell surface.

UniProt: Q08351

Pathways: Signalistation JAK/STAT