FBLN3 Kit ELISA

N° du produit ABIN5510647

Détail du produit FBLN3 Kit ELISA

Antigène: FBLN3 (Fibulin 3 (FBLN3))

Épitope: AA 18-493

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Fibulin-3/EFEMP1

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: CHO
Immunogen sequence: Q18-F493

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina. .

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: FBLN3 (Fibulin 3 (FBLN3))

Autre désignation: EFEMP1 (FBLN3 Produits)

Synonymes: DHRD Kit ELISA, DRAD Kit ELISA, FBLN3 Kit ELISA, FBNL Kit ELISA, FIBL-3 Kit ELISA, MLVT Kit ELISA, MTLV Kit ELISA, S1-5 Kit ELISA, T16 Kit ELISA, EGF containing fibulin like extracellular matrix protein 1 Kit ELISA, EGF-containing fibulin-like extracellular matrix protein 1 Kit ELISA, epidermal growth factor-containing fibulin-like extracellular matrix protein 1 Kit ELISA, EFEMP1 Kit ELISA, Efemp1 Kit ELISA

Sujet:

Protein Function: Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. .

Background: EGF-containing fibulin-like extracellular matrix protein 1 is a protein that in humans is encoded by the EFEMP1 gene. This gene encodes a member of the fibulin family of extracellular matrix glycoproteins. Like all members of this family, the encoded protein contains tandemly repeated epidermal growth factor-like repeats followed by a C-terminus fibulin-type domain. This gene is upregulated in malignant gliomas and may play a role in the aggressive nature of these tumors. Mutations in this gene are associated with Doyne honeycomb retinal dystrophy. Alternatively spliced transcript variants that encode the same protein have been described.

Synonyms: EGF-containing fibulin-like extracellular matrix protein 1,Extracellular protein S1-5,Fibrillin-like protein,Fibulin-3,FIBL-3,EFEMP1,FBLN3, FBNL,

Full Gene Name: EGF-containing fibulin-like extracellular matrix protein 1

Cellular Localisation: Secreted, extracellular space . Secreted, extracellular space, extracellular matrix . Localizes to the lamina propria underneath the olfactory epithelium..

UniProt: Q12805

Pathways: EGFR Signaling Pathway