R-Spondin 4 Kit ELISA

N° du produit ABIN5510660

Détail du produit R-Spondin 4 Kit ELISA

Antigène: R-Spondin 4 (RSPO4)

Épitope: AA 20-234

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human R-Spondin-4

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: L20-P234

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: R-Spondin 4 (RSPO4)

Autre désignation: RSPO4 (RSPO4 Produits)

Synonymes: RGD1563415 Kit ELISA, RSPO4-like Kit ELISA, C20orf182 Kit ELISA, CRISTIN4 Kit ELISA, A730099F22 Kit ELISA, A930029K19Rik Kit ELISA, R-spondin 4 Kit ELISA, RSPO4 Kit ELISA, Rspo4 Kit ELISA

Sujet:

Protein Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. .

Background: R-spondin 4 is a protein in humans that is encoded by the RSPO4 gene. It is mapped to chromosome 20p13. This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.

Synonyms: R-spondin-4,Roof plate-specific spondin-4,hRspo4,RSPO4,C20orf182,

Full Gene Name: R-spondin-4

Cellular Localisation: Secreted.

UniProt: Q2I0M5