R-Spondin 3 Kit ELISA

N° du produit ABIN5510682

Détail du produit R-Spondin 3 Kit ELISA

Antigène: R-Spondin 3 (RSPO3)

Épitope: AA 22-272

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human R-Spondin-3

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: Q22-H272

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Ubiquitously expressed. Expressed at higher level in placenta, small intestine, fetal thymus and lymph node (PubMed:12463421). Highly expressed in endothelial cells (PubMed:26766444). .

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: R-Spondin 3 (RSPO3)

Autre désignation: RSPO3 (RSPO3 Produits)

Synonymes: pwtsr Kit ELISA, thsd2 Kit ELISA, cristin1 Kit ELISA, CRISTIN1 Kit ELISA, PWTSR Kit ELISA, THSD2 Kit ELISA, RGD1563246 Kit ELISA, 2810459H04Rik Kit ELISA, AW742308 Kit ELISA, Cristin1 Kit ELISA, Thsd2 Kit ELISA, R-spondin 3 Kit ELISA, rspo3 Kit ELISA, RSPO3 Kit ELISA, Rspo3 Kit ELISA

Sujet:

Protein Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta- catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity). .

Background: R-spondin-3 is a protein that in humans is encoded by the RSPO3 gene. This gene belongs to the R-spondin family. The encoded protein plays a role in the regulation of Wnt (wingless-type MMTV integration site family)/beta-catenin and Wnt/planar cell polarity (PCP) signaling pathways, which are involved in development, cell growth and disease pathogenesis. Genome-wide association studies suggest a correlation of this gene with bone mineral density and risk of fracture. This gene may be involved in tumor development.

Synonyms: R-spondin-3,Protein with TSP type-1 repeat,hPWTSR,Roof plate-specific spondin-3,hRspo3,Thrombospondin type-1 domain-containing protein 2,RSPO3,PWTSR, THSD2,

Full Gene Name: R-spondin-3

Cellular Localisation: Secreted.

UniProt: Q9BXY4