RSPO1 Kit ELISA

N° du produit ABIN5510684

Détail du produit RSPO1 Kit ELISA

Antigène: RSPO1 (R-Spondin 1 (RSPO1))

Épitope: AA 21-263

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human R-Spondin-1

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: S21-A263

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Abundantly expressed in adrenal glands, ovary, testis, thyroid and trachea but not in bone marrow, spinal cord, stomach, leukocytes colon, small intestine, prostate, thymus and spleen. .

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: RSPO1 (R-Spondin 1 (RSPO1))

Autre désignation: RSPO1 (RSPO1 Produits)

Synonymes: RGD1565558 Kit ELISA, CRISTIN3 Kit ELISA, RSPO Kit ELISA, R-spondin Kit ELISA, Rspondin Kit ELISA, wu:fj81e05 Kit ELISA, zgc:92153 Kit ELISA, R-spondin 1 Kit ELISA, Rspo1 Kit ELISA, RSPO1 Kit ELISA, LOC100049655 Kit ELISA, rspo1 Kit ELISA

Sujet:

Protein Function: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination. .

Background: R-spondin-1 is a secreted protein that in humans is encoded by the Rspo1 gene. It is mapped to chromosome 1p34. This gene encodes a secreted activator protein with two cysteine-rich, furin-like domains and one thrombospondin type 1 domain. The encoded protein is a ligand for leucine-rich repeat-containing G-protein coupled receptors (LGR proteins) and positively regulates the Wnt signaling pathway. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy- induced adverse effects. Alternative splicing results in multiple transcript variants.

Synonyms: R-spondin-1,Roof plate-specific spondin-1,hRspo1,RSPO1,

Full Gene Name: R-spondin-1

Cellular Localisation: Secreted . Nucleus . Seems to mainly localize to nucleoli..

UniProt: Q2MKA7