LGMN Kit ELISA

N° du produit ABIN5510723

Détail du produit LGMN Kit ELISA

Antigène: LGMN (Legumain (LGMN))

Épitope: AA 18-433

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Legumain(total)

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO
Immunogen sequence: V18-Y433

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Ubiquitous. Particularly abundant in kidney, heart and placenta.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: LGMN (Legumain (LGMN))

Autre désignation: LGMN (LGMN Produits)

Synonymes: AEP Kit ELISA, LGMN1 Kit ELISA, PRSC1 Kit ELISA, AI746452 Kit ELISA, AU022324 Kit ELISA, Prsc1 Kit ELISA, MGC64351 Kit ELISA, cb173 Kit ELISA, cb460 Kit ELISA, sb:cb173 Kit ELISA, zgc:76953 Kit ELISA, wu:fa98g05 Kit ELISA, wu:fj92g08 Kit ELISA, lgmn Kit ELISA, MGC88980 Kit ELISA, DELTA VACUOLAR PROCESSING ENZYME Kit ELISA, DELTAVPE Kit ELISA, delta vacuolar processing enzyme Kit ELISA, legumain Kit ELISA, legumain L homeolog Kit ELISA, delta vacuolar processing enzyme Kit ELISA, Legumain Kit ELISA, LGMN Kit ELISA, Lgmn Kit ELISA, lgmn.L Kit ELISA, lgmn Kit ELISA, DELTA-VPE Kit ELISA, MBOO_RS07785 Kit ELISA, Odosp_3582 Kit ELISA, LOC569153 Kit ELISA

Sujet:

Protein Function: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. .

Background: Legumain (asparaginyl endopeptidase, citvac, proteinase B, hemoglobinase, PRSC1 gene product or LGMN (Homo sapiens), vicilin peptidohydrolase, bean endopeptidase) is an enzyme that in humans is encoded by the LGMN gene (previous symbolPRSC1). Using fluorescence in situ hybridization, the LGMN gene was mapped to chromosome 14q32.1. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types.

Synonyms: Legumain,3.4.22.34,Asparaginyl endopeptidase,Protease, cysteine 1,LGMN,PRSC1,

Full Gene Name: Legumain

Cellular Localisation: Lysosome.

UniProt: Q99538

Pathways: Metabolism of Steroid Hormones and Vitamin D, Activation of Innate immune Response, Toll-Like Receptors Cascades