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SIGLEC5 Kit ELISA

SIGLEC5 Reactivité: Humain AA 17-441 Colorimetric Sandwich ELISA
N° du produit ABIN5510738
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    SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))
    Épitope
    AA 17-441
    Reactivité
    • 3
    • 1
    Humain
    Méthode de détection
    Colorimetric
    Type de méthode
    Sandwich ELISA
    Application
    ELISA
    Fonction
    Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human Siglec5
    Marque
    PicoKine™
    Analytical Method
    Quantitative
    Specificité
    Expression system for standard: NSO, Immunogen sequence: E17-L441
    Réactivité croisée (Details)
    There is no detectable cross-reactivity with other relevant proteins.
    Attributs du produit

    Tissue Specificity: Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation.

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  • Plaque
    Pre-coated
    Restrictions
    For Research Use only
  • Stock
    4 °C,-20 °C
    Stockage commentaire
    Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)
    Date de péremption
    12 months
  • Antigène Voir toutes SIGLEC5 Kits ELISA
    SIGLEC5 (Sialic Acid Binding Ig-Like Lectin 5 (SIGLEC5))
    Autre désignation
    SIGLEC5 (SIGLEC5 Produits)
    Synonymes
    CD170 Kit ELISA, CD33L2 Kit ELISA, OB-BP2 Kit ELISA, OBBP2 Kit ELISA, SIGLEC-5 Kit ELISA, sialic acid binding Ig like lectin 5 Kit ELISA, sialic acid-binding Ig-like lectin 5 Kit ELISA, sialic acid binding Ig-like lectin 5 Kit ELISA, SIGLEC5 Kit ELISA, LOC100597560 Kit ELISA, Siglec5 Kit ELISA
    Sujet

    Protein Function: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

    Background: Sialic acid-binding Ig-like lectin 5 is a protein that in humans is encoded by the SIGLEC5 gene. This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion.

    Synonyms: Sialic acid-binding Ig-like lectin 5,Siglec-5,CD33 antigen-like 2,Obesity-binding protein 2,OB-BP2,OB-binding protein 2,CD170,SIGLEC5,CD33L2, OBBP2,

    Full Gene Name: Sialic acid-binding Ig-like lectin 5

    Cellular Localisation: Membrane, Single-pass type I membrane protein.
    UniProt
    O15389
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