ULBP2 Kit ELISA

N° du produit ABIN5510744

Détail du produit ULBP2 Kit ELISA

Antigène: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Épitope: AA 26-216

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human ULBP2

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO, Immunogen sequence: G26-S216

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: Expressed in various types of cancer cell lines and in the fetus, but not in normal tissues. .

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Autre désignation: ULBP2 (ULBP2 Produits)

Synonymes: N2DL2 Kit ELISA, RAET1H Kit ELISA, UL16 binding protein 2 Kit ELISA, NKG2D ligand 2-like Kit ELISA, ULBP2 Kit ELISA, LOC100355436 Kit ELISA

Sujet:

Protein Function: Ligand for the KLRK1/NKG2D receptor, together with at least ULBP1 and ULBP3. ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to KLRK1/NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked the interaction with the KLRK1/NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system. UL16 also causes ULBP2 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface. .

Background: UL16 binding protein 2 (ULBP2) is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6. This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells.

Synonyms: NKG2D ligand 2,N2DL-2,NKG2DL2,ALCAN-alpha,Retinoic acid early transcript 1H,UL16-binding protein 2,ULBP2,N2DL2, RAET1H,UNQ463/PRO791,

Full Gene Name: NKG2D ligand 2

Cellular Localisation: Cell membrane, Lipid-anchor, GPI-anchor. Secreted.

UniProt: Q9BZM5