Notch1 Kit ELISA

N° du produit ABIN5510756

Détail du produit Notch1 Kit ELISA

Antigène: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Épitope: AA 19-526

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human NOTCH1

Marque: PicoKine™

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO, Immunogen sequence: A19-Q526

Réactivité croisée (Details): There is no detectable cross-reactivity with other relevant proteins.

Attributs du produit:

Tissue Specificity: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.

Information d'application

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: Notch1 (NOTCH1) (Notch 1 (NOTCH1))

Autre désignation: NOTCH1 (NOTCH1 Produits)

Synonymes: notch1 Kit ELISA, NOTCH1 Kit ELISA, hn1 Kit ELISA, tan1 Kit ELISA, notch Kit ELISA, xotch Kit ELISA, xnotch Kit ELISA, notch-1 Kit ELISA, xnotch1 Kit ELISA, TAN1 Kit ELISA, hN1 Kit ELISA, 9930111A19Rik Kit ELISA, Mis6 Kit ELISA, N1 Kit ELISA, Tan1 Kit ELISA, lin-12 Kit ELISA, NOTCH Kit ELISA, Xotch Kit ELISA, notch1-a Kit ELISA, notch 1 Kit ELISA, fibropellin-1 Kit ELISA, Notch homolog 1, translocation-associated (Drosophila) Kit ELISA, Notch homolog 1, translocation-associated Kit ELISA, notch 1 S homeolog Kit ELISA, notch1 Kit ELISA, LOC100631526 Kit ELISA, NOTCH1 Kit ELISA, Notch1 Kit ELISA, notch1.S Kit ELISA

Sujet:

Protein Function: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis, negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

Background: Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis, and the activated Notch 1 and Notch 3 promote differentiation of progenitor cells into astroglia.

Synonyms: Neurogenic locus notch homolog protein 1, Notch 1, hN1, Translocation-associated notch protein TAN-1, Notch 1 extracellular truncation, NEXT, Notch 1 intracellular domain, NICD, NOTCH1, TAN1,

Full Gene Name: notch 1

Cellular Localisation: Cell membrane, Single-pass type I membrane protein.

UniProt: P46531

Pathways: Signalisation Notch, Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development