DC-SIGN/CD209 Kit ELISA

N° du produit ABIN5692223

Détail du produit DC-SIGN/CD209 Kit ELISA

Antigène: DC-SIGN/CD209 (CD209) (CD209)

Épitope: AA 59-404

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Gamme de detection: 93.7 pg/mL - 6000 pg/mL

Seuil minimal de détection: 93.7 pg/mL

Application: ELISA

Fonction: Sandwich High Sensitivity ELISA kit for Quantitative Detection of Human CD209. 96wells/kit, with removable strips.

Marque: PicoKine™

Type d'échantillon: Cell Culture Supernatant, Plasma (EDTA - heparin), Serum

Analytical Method: Quantitative

Specificité: Expression system for standard: NSO, Immunogen sequence: Q59-A404

Sensibilité: < 10 pg/mL

Ingrédients: 96-well plate precoated with antibody
lyophilized recombinant standard
biotinylated antibody (dilution 1:100)
Avidin-Biotin-Peroxidase Complex(ABC)(dilution 1:100)
Sample diluent buffer
Antibody diluent buffer
ABC diluent buffer
TMB color developing agent
TMB stop solution
Adhesive cover

Information d'application

Durée du test: 15 min

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles(Shipped with wet ice.)

Date de péremption: 12 months

Détail du antigène

Antigène: DC-SIGN/CD209 (CD209) (CD209)

Autre désignation: CD209 (CD209 Produits)

Synonymes: CDSIGN Kit ELISA, CLEC4L Kit ELISA, DC-SIGN Kit ELISA, DC-SIGN1 Kit ELISA, cd209 Kit ELISA, CLEC4M Kit ELISA, si:ch211-224h1.3 Kit ELISA, CD209 Kit ELISA, CIRE Kit ELISA, Dcsign Kit ELISA, SIGN-R1 Kit ELISA, SIGNR5 Kit ELISA, Cd209 Kit ELISA, CD209 molecule Kit ELISA, CD209a antigen Kit ELISA, CD209 antigen-like protein D Kit ELISA, CD209c molecule Kit ELISA, CD209 antigen Kit ELISA, CD209 Kit ELISA, cd209 Kit ELISA, Cd209a Kit ELISA, LOC100529184 Kit ELISA, Cd209c Kit ELISA, LOC100460708 Kit ELISA, LOC105484282 Kit ELISA

Sujet:

Synonyms: CD209 antigen, C-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN, DC-SIGN1, CD209, CD209, CLEC4L

Tissue Specificity: Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.

Background: DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene. This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene. DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Cellular Localisation: Isoform 1: Cell membrane, Single-pass type II membrane protein.

UniProt: Q9NNX6