Corin Kit ELISA

N° du produit ABIN6720220

Détail du produit Corin Kit ELISA

Antigène: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Reactivité: Humain

Méthode de détection: Colorimetric

Type de méthode: Sandwich ELISA

Gamme de detection: 62.5 pg/mL - 4000 pg/mL

Seuil minimal de détection: 62.5 pg/mL

Application: ELISA

Fonction: Sandwich ELISA for Quantitative Detection of Antigen

Type d'échantillon: Cell Culture Supernatant, Plasma (EDTA - heparin), Serum

Analytical Method: Quantitative

Attributs du produit:

Synonyms: activated protease fragment, ATC 2, ATC2, Atrial natriuretic peptide-converting enzyme, Atrial natriuteric peptide converting enzyme, Corin, Corin serine peptidase, CORIN_HUMAN, CRN, Heart specific serine proteinase, Heart specific serine proteinase ATC2, Heart-specific serine proteinase ATC2, Lrp 4, Lrp4, MGC119742, Pro ANP convertase, Pro ANP converting enzyme, Pro-ANP-converting enzyme, TMPRSS 10, TMPRSS10, Transmembrane protease serine 10

Background: Atrial natriuretic peptide-converting enzyme, also called CRN or ATC2, is a protein that in humans is encoded by the CORIN gene. It is mapped to 4p12. This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. It has been found that Corin is the pro-ANP-converting enzyme and that Corin-mediated pro-ANP activation may play a role in regulating blood pressure. What's more, Corin and ANP are essential for physiologic changes at the maternal-fetal interface. This protein may also function as a pro-brain-type natriuretic peptide convertase. Corin gene mutations which cause Corin to impair activity might be an underlying mechanism in hypertension.

Gene Name: CORIN

Production: Natural and recombinant human Corin. There is no detectable cross-reactivity with other relevant proteins.

Standard: Expression system for standard: NSO, Immunogen sequence: S67-N1042

Information d'application

Indications d'application:

Application Note: Useful in Sandwich ELISA for Quantitative Detection of Antigen. Aliquot 0.1 mL per well of the 4000pg/mL, 2000pg/mL, 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL human Corin standard solutions into the precoated 96-well plate. Add 0.1 mL of the sample diluent buffer into the control well (Zero well). Add 0.1 mL of each properly diluted sample of human cell culture supernates, serum, plasma(heparin, EDTA) or tissue homogenates to each empty well. It is recommended that each human Corin standard solution and each sample be measured in duplicate.

Blood Product Anticoagulant: Heparin Sodium

ELISA Dilution: 62.5pg/mL-4000pg/mL

Volume d'échantillon: 100 μL

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: RT,4 °C,-20 °C

Stockage commentaire: Store vials at 4°C prior to opening. Centrifuge product if not completely clear after standing at room temperature. This product is stable for 6 months at 4°C as an undiluted liquid. Dilute only prior to immediate use. For extended storage freeze at -20°C or below for 12 months. Avoid cycles of freezing and thawing.

Détail du antigène

Antigène: Corin (CORIN) (Corin, Serine Peptidase (CORIN))

Autre désignation: Corin (CORIN Produits)

Synonymes: CORIN Kit ELISA, CG2105 Kit ELISA, Dmel\\CG2105 Kit ELISA, SP75 Kit ELISA, LOC559109 Kit ELISA, AV273130 Kit ELISA, Lrp4 Kit ELISA, ATC2 Kit ELISA, CRN Kit ELISA, PEE5 Kit ELISA, TMPRSS10 Kit ELISA, corin, serine peptidase Kit ELISA, CG2105 gene product from transcript CG2105-RC Kit ELISA, novel protein similar to H.sapiens CORIN, corin, serine peptidase (CORIN) Kit ELISA, corin Kit ELISA, CORIN Kit ELISA, Corin Kit ELISA, LOC559109 Kit ELISA

ID gène: 10699

NCBI Accession: NP_001265514

UniProt: Q9Y5Q5

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones