PRTN3 Kit ELISA

N° du produit ABIN996889

Détail du produit PRTN3 Kit ELISA

Antigène: PRTN3 (Proteinase 3 (PRTN3))

Méthode de détection: Colorimetric

Type de méthode: Competition ELISA

Application: ELISA

Fonction: Proteinase-3 (PR-3) Enzyme-Linked Immunosorbent Assay (ELISA) is intended for the detection and semiquantitative determination of antibodies to PR-3 in human sera. The assay is to be used to detect antibodies in a single serum specimen. The results of the assay are to be used as an aid in the diagnosis of Wegener’s granulomatosis

Analytical Method: Semi-Quantitative

Specificité: 95.6%

Sensibilité: 98.2%

Information d'application

Volume d'échantillon: 10 μL

Durée du test: 1 - 2 h

Plaque: Pre-coated

Restrictions: For Research Use only

Stockage

Stock: 4 °C

Date de péremption: 12 months

Détail du antigène

Antigène: PRTN3 (Proteinase 3 (PRTN3))

Autre désignation: PR3 (c-ANCA) (PRTN3 Produits)

Synonymes: ela2 Kit ELISA, MGC132250 Kit ELISA, ACPA Kit ELISA, AGP7 Kit ELISA, C-ANCA Kit ELISA, CANCA Kit ELISA, MBN Kit ELISA, MBT Kit ELISA, NP-4 Kit ELISA, NP4 Kit ELISA, P29 Kit ELISA, PR-3 Kit ELISA, PR3 Kit ELISA, mPR3 Kit ELISA, proteinase 3 L homeolog Kit ELISA, proteinase 3 Kit ELISA, prtn3.L Kit ELISA, PRTN3 Kit ELISA, Prtn3 Kit ELISA

Sujet: Proteinase-3 is a lysosomal enzyme that can be found in human neutrophils. There are two subsets of autoantibodies to human neutrophils: c- ANCA and p-ANCA. The first subtype, c-ANCA, shows cytoplasmic staining by IFA and is diagnostic for Wegener's granulomatosis. The major antigen responsible for the c-ANCA staining is Proteinase-3. The second subtype, p-ANCA, shows perinuclear staining by IFA. The major antigen responsible for the p-ANCA response has been shown to be myeloperoxidase. The ANCA staining patterns are obtained using ethanol-fixed human neutrophils. Anti- PR-3 autoantibodies have been associated with Wegener's granulomatosis but less often with microscopic polyangiitis. Other antigen specificity's (CAP 57) can be responsible for the c-ANCA pattern. These antigens are generally not diagnostic for PR-3 associated vaculitus diseases.