LATS1 Produits
(LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) (LATS1))
Catégories
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.
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Catégories LATS1 en vedette
LATS1 Anticorps
High quality antibodies with extensive validation data.
LATS1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IP, IF
Validations
- (5)
N° du produit
ABIN7169059
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (1)
- (2)
N° du produit
ABIN391033
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
N° du produit
ABIN522568
Quantité
100 μg
Fiche technique
Fiche technique
LATS1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968208
Quantité
96 tests
Fiche technique
Fiche technique
LATS1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123723
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309191
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5508984
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits LATS1
: "STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle." dans: Cells, Vol. 8, Issue 12, (2020) (PubMed).: "The polarity protein Angiomotin p130 controls dendritic spine maturation." dans: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).
: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." dans: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).
: "Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration." dans: American journal of physiology. Gastrointestinal and liver physiology, Vol. 307, Issue 2, pp. G196-204, (2014) (PubMed).
: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." dans: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).
: "YAP modifies cancer cell sensitivity to EGFR and survivin inhibitors and is negatively regulated by the non-receptor type protein tyrosine phosphatase 14." dans: Oncogene, Vol. 32, Issue 17, pp. 2220-9, (2013) (PubMed).
: "Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity." dans: Cancer research, Vol. 71, Issue 5, pp. 2010-20, (2011) (PubMed).
: "Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development." dans: Development (Cambridge, England), Vol. 138, Issue 5, pp. 947-57, (2011) (PubMed).
: "Crucial role for Mst1 and Mst2 kinases in early embryonic development of the mouse." dans: Molecular and cellular biology, Vol. 29, Issue 23, pp. 6309-20, (2009) (PubMed).
: "Identification of novel posttranscriptional targets of the BCR/ABL oncoprotein by ribonomics: requirement of E2F3 for BCR/ABL leukemogenesis." dans: Blood, Vol. 111, Issue 2, pp. 816-28, (2008) (PubMed).
Synonymes et noms alternatifs relatifs à LATS1
large tumor suppressor kinase 1 (LATS1), large tumor suppressor (Lats1), large tumor suppressor kinase 1 (lats1), large tumor suppressor kinase 1 (Lats1), large tumor suppressor kinase 1 S homeolog (lats1.S), AW208599, Lats, lats1, RGD1564085, si:dkey-181i3.5, WARTS, warts, wts, wu:fc19a11, zgc:123219Protein level used designations for LATS1
- LATS (large tumor suppressor, Drosophila) homolog 1
- LATS, large tumor suppressor, homolog 1
- WARTS protein kinase
- h-warts
- large tumor suppressor homolog 1
- serine/threonine-protein kinase LATS1
- large tumor supressor, homolog 1
- large tumor suppressor 1
- large tumor suppressor
- LATS homolog 1
- LATS, large tumor suppressor, homolog 1 (Drosophila)
- serine/threonine-protein kinase LATS1-like
- large tumor suppressor kinase 1 S homeolog
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