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LATS2 Produits

(LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))

Catégories

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

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Catégories LATS2 en vedette

LATS2 Anticorps

High quality antibodies with extensive validation data.

LATS2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
  • (1)
  • (2)
N° du produit ABIN753568
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Mouse
Application WB, IHC (p)
Validations
  • (4)
  • (2)
N° du produit ABIN1881491
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC
Validations
  • (3)
N° du produit ABIN7268192
Quantité 100 μL
Fiche technique Fiche technique

LATS2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6968209
Quantité 96 tests
Fiche technique Fiche technique

LATS2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123724
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5508985
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3093544
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits LATS2

Wigerius, Quinn, Diab, Clattenburg, Kolar, Qi, Krueger, Fawcett: "The polarity protein Angiomotin p130 controls dendritic spine maturation." dans: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).

Zhang, Wang, Xie, Chen, Sinkemani, Yu, Wang, Mao, Wu: "Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence." dans: Oncotarget, Vol. 9, Issue 2, pp. 2175-2192, (2018) (PubMed).

Wang, Sinnett-Smith, Stevens, Young, Rozengurt et al.: "Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR ..." dans: The Journal of biological chemistry, Vol. 291, Issue 34, pp. 17988-8005, (2016) (PubMed).

Tanaka, Osada, Fujii, Fukatsu, Hida, Horio, Kondo, Sato, Hasegawa, Tsujimura, Sekido: "LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade." dans: Oncogene, Vol. 34, Issue 1, pp. 73-83, (2015) (PubMed).

Staedel, Varon, Nguyen, Vialet, Chambonnier, Rousseau, Soubeyran, Evrard, Couillaud, Darfeuille: "Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors." dans: Molecular therapy. Nucleic acids, Vol. 4, pp. e246, (2015) (PubMed).

Xiang, Gilkes, Hu, Takano, Luo, Lu, Bullen, Samanta, Liang, Semenza: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." dans: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).

Pefani, Latusek, Pires, Grawenda, Yee, Hamilton, van der Weyden, Esashi, Hammond, ONeill: "RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2." dans: Nature cell biology, Vol. 16, Issue 10, pp. 962-71, 1-8, (2014) (PubMed).

Reuven, Adler, Meltser, Shaul: "The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl." dans: Cell death and differentiation, Vol. 20, Issue 10, pp. 1330-40, (2013) (PubMed).

Chan, Lim, Guo, Tan, Leung, Hong: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." dans: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).

Zhang, Iyer, Chowdhury, Ji, Xiao, Yang, Chen, Tsai, Dong: "KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis." dans: The Journal of biological chemistry, Vol. 287, Issue 41, pp. 34069-77, (2012) (PubMed).

Synonymes et noms alternatifs relatifs à LATS2

large tumor suppressor kinase 2 (LATS2), large tumor suppressor 2 (Lats2), large tumor suppressor kinase 2 (Lats2), large tumor suppressor kinase 2 (lats2), 4932411G09Rik, AV277261, AW228608, KPM, lats2

Protein level used designations for LATS2

  • kinase phosphorylated during mitosis protein
  • large tumor suppressor homolog 2
  • serine/threonine-protein kinase LATS2
  • serine/threonine-protein kinase kpm
  • large tumor suppressor, homolog 2
  • LATS (large tumor suppressor, Drosophila) homolog 2
  • LATS, large tumor suppressor, homolog 2
  • serine/threonine kinase KPM
  • warts-like kinase
  • large tumor suppressor 2-like protein
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