LATS2 Produits
(LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) (LATS2))
Catégories
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
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Catégories LATS2 en vedette
LATS2 Anticorps
High quality antibodies with extensive validation data.
LATS2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (1)
- (2)
N° du produit
ABIN753568
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC (p)
Validations
- (4)
- (2)
N° du produit
ABIN1881491
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (3)
N° du produit
ABIN7268192
Quantité
100 μL
Fiche technique
Fiche technique
LATS2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968209
Quantité
96 tests
Fiche technique
Fiche technique
LATS2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123724
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5508985
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3093544
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits LATS2
: "The polarity protein Angiomotin p130 controls dendritic spine maturation." dans: The Journal of cell biology, Vol. 217, Issue 2, pp. 715-730, (2018) (PubMed).: "Dysregulation of YAP by the Hippo pathway is involved in intervertebral disc degeneration, cell contact inhibition, and cell senescence." dans: Oncotarget, Vol. 9, Issue 2, pp. 2175-2192, (2018) (PubMed).
: "Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR ..." dans: The Journal of biological chemistry, Vol. 291, Issue 34, pp. 17988-8005, (2016) (PubMed).
: "LIM-domain protein AJUBA suppresses malignant mesothelioma cell proliferation via Hippo signaling cascade." dans: Oncogene, Vol. 34, Issue 1, pp. 73-83, (2015) (PubMed).
: "Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors." dans: Molecular therapy. Nucleic acids, Vol. 4, pp. e246, (2015) (PubMed).
: "Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype." dans: Oncotarget, Vol. 5, Issue 24, pp. 12509-27, (2015) (PubMed).
: "RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2." dans: Nature cell biology, Vol. 16, Issue 10, pp. 962-71, 1-8, (2014) (PubMed).
: "The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl." dans: Cell death and differentiation, Vol. 20, Issue 10, pp. 1330-40, (2013) (PubMed).
: "Actin-binding and cell proliferation activities of angiomotin family members are regulated by Hippo pathway-mediated phosphorylation." dans: The Journal of biological chemistry, Vol. 288, Issue 52, pp. 37296-307, (2013) (PubMed).
: "KIBRA regulates aurora kinase activity and is required for precise chromosome alignment during mitosis." dans: The Journal of biological chemistry, Vol. 287, Issue 41, pp. 34069-77, (2012) (PubMed).
Synonymes et noms alternatifs relatifs à LATS2
large tumor suppressor kinase 2 (LATS2), large tumor suppressor 2 (Lats2), large tumor suppressor kinase 2 (Lats2), large tumor suppressor kinase 2 (lats2), 4932411G09Rik, AV277261, AW228608, KPM, lats2Protein level used designations for LATS2
- kinase phosphorylated during mitosis protein
- large tumor suppressor homolog 2
- serine/threonine-protein kinase LATS2
- serine/threonine-protein kinase kpm
- large tumor suppressor, homolog 2
- LATS (large tumor suppressor, Drosophila) homolog 2
- LATS, large tumor suppressor, homolog 2
- serine/threonine kinase KPM
- warts-like kinase
- large tumor suppressor 2-like protein
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