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LCK Produits

(Lymphocyte-Specific Protein tyrosine Kinase (LCK))

Catégories

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].

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Catégories LCK en vedette

LCK Anticorps

High quality antibodies with extensive validation data.

LCK Kits ELISA

Reliable ELISA kits for a wide range of species.

LCK Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

LCK recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IP, RNAi
Validations
  • (6)
N° du produit ABIN561649
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC
Validations
  • (6)
N° du produit ABIN3023130
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, FACS, IP, ICC
Validations
  • (7)
  • (4)
N° du produit ABIN94422
Quantité 0.1 mg
Fiche technique Fiche technique

LCK recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
N° du produit ABIN4886174
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1380629
Quantité 2 x 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1380225
Quantité 2 x 96 tests
Fiche technique Fiche technique

LCK recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1309226
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1309224
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5508986
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits LCK

Fukasawa, Yoshizaki, Ebata, Yoshizaki-Ogawa, Asano, Enomoto, Miyagawa, Kazoe, Mawatari, Kitamori, Sato: "Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model." dans: eLife, Vol. 10, (2021) (PubMed).

Stepanek, Kalina, Draber, Skopcova, Svojgr, Angelisova, Horejsi, Weiss, Brdicka: "Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148." dans: The Journal of biological chemistry, Vol. 286, Issue 25, pp. 22101-12, (2011) (PubMed).

Hrdinka, Dráber, Stepánek, Ormsby, Otáhal, Angelisová, Brdicka, Paces, Horejsí, Drbal: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." dans: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).

Feng, Lucchinetti, Enkavi, Wang, Gehrig, Roschitzki, Schaub, Tajkhorshid, Zaugg, Zaugg: "Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria." dans: American journal of physiology. Cell physiology, Vol. 298, Issue 3, pp. C740-8, (2010) (PubMed).

Ota: "The effects of membrane compartmentalization of Csk on TCR signaling." dans: Biochimica et biophysica acta, (2010) (PubMed).

Geelhaar, Moos, Schinnerling, Allers, Loddenkemper, Fenollar, LaScola, Raoult, Schneider: "Specific and nonspecific B-cell function in the small intestines of patients with Whipple's disease." dans: Infection and immunity, Vol. 78, Issue 11, pp. 4589-92, (2010) (PubMed).

Park, Jun, Han, Kim: "Protein tyrosine kinase p56lck-deficiency confers hypersusceptibility to rho-fluorophenylalanine (pFPhe)-induced apoptosis by augmenting mitochondrial apoptotic pathway in human Jurkat T cells." dans: Biochemical and biophysical research communications, Vol. 377, Issue 1, pp. 280-5, (2008) (PubMed).

Monu, Frey: "Suppression of proximal T cell receptor signaling and lytic function in CD8+ tumor-infiltrating T cells." dans: Cancer research, Vol. 67, Issue 23, pp. 11447-54, (2007) (PubMed).

Meraner, Horejsí, Wolpl, Fischer, Stingl, Maurer: "Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 4, pp. 2262-71, (2007) (PubMed).

Shi, Cooper, Yu: "A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation." dans: Molecular cancer research : MCR, Vol. 4, Issue 1, pp. 39-45, (2006) (PubMed).

Synonymes et noms alternatifs relatifs à LCK

LCK proto-oncogene, Src family tyrosine kinase (lck), LCK proto-oncogene, Src family tyrosine kinase (LCK), lymphocyte protein tyrosine kinase (Lck), LCK proto-oncogene, Src family tyrosine kinase (Lck), Hck-3, LCK, Lck1, Lcktkr, Lsk, LSK, Lskt, p56, p56Lck, p56lck, P56LCK, pp58lck, tkl, YT16, zgc:136695

Protein level used designations for LCK

  • lymphocyte protein tyrosine kinase
  • lymphocyte-specific protein tyrosine kinase
  • tyrosine-protein kinase Lck-like
  • leukocyte C-terminal Src kinase
  • lymphocyte cell-specific protein-tyrosine kinase
  • proto-oncogene tyrosine-protein kinase LCK
  • T-lymphocyte specific protein tyrosine kinase p56lck
  • p56(LSTRA) protein-tyrosine kinase
  • t cell-specific protein-tyrosine kinase
  • tyrosine-protein kinase Lck
  • tyrosine protein kinase
  • tyrosine-protein kinase LCK
  • p56-LCK
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