LCK Produits
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Catégories
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008].
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Catégories LCK en vedette
LCK Anticorps
High quality antibodies with extensive validation data.
LCK Kits ELISA
Reliable ELISA kits for a wide range of species.
LCK Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
LCK recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IP, RNAi
Validations
- (6)
N° du produit
ABIN561649
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (6)
N° du produit
ABIN3023130
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, FACS, IP, ICC
Validations
- (7)
- (4)
N° du produit
ABIN94422
Quantité
0.1 mg
Fiche technique
Fiche technique
LCK recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4886174
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380629
Quantité
2 x 96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380225
Quantité
2 x 96 tests
Fiche technique
Fiche technique
LCK recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309226
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309224
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5508986
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits LCK
: "Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model." dans: eLife, Vol. 10, (2021) (PubMed).: "Regulation of Src family kinases involved in T cell receptor signaling by protein-tyrosine phosphatase CD148." dans: The Journal of biological chemistry, Vol. 286, Issue 25, pp. 22101-12, (2011) (PubMed).
: "PRR7 is a transmembrane adaptor protein expressed in activated T cells involved in regulation of T cell receptor signaling and apoptosis." dans: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19617-29, (2011) (PubMed).
: "Tyrosine phosphorylation by Src within the cavity of the adenine nucleotide translocase 1 regulates ADP/ATP exchange in mitochondria." dans: American journal of physiology. Cell physiology, Vol. 298, Issue 3, pp. C740-8, (2010) (PubMed).
: "The effects of membrane compartmentalization of Csk on TCR signaling." dans: Biochimica et biophysica acta, (2010) (PubMed).
: "Specific and nonspecific B-cell function in the small intestines of patients with Whipple's disease." dans: Infection and immunity, Vol. 78, Issue 11, pp. 4589-92, (2010) (PubMed).
: "Protein tyrosine kinase p56lck-deficiency confers hypersusceptibility to rho-fluorophenylalanine (pFPhe)-induced apoptosis by augmenting mitochondrial apoptotic pathway in human Jurkat T cells." dans: Biochemical and biophysical research communications, Vol. 377, Issue 1, pp. 280-5, (2008) (PubMed).
: "Suppression of proximal T cell receptor signaling and lytic function in CD8+ tumor-infiltrating T cells." dans: Cancer research, Vol. 67, Issue 23, pp. 11447-54, (2007) (PubMed).
: "Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 4, pp. 2262-71, (2007) (PubMed).
: "A constitutively active Lck kinase promotes cell proliferation and resistance to apoptosis through signal transducer and activator of transcription 5b activation." dans: Molecular cancer research : MCR, Vol. 4, Issue 1, pp. 39-45, (2006) (PubMed).
Synonymes et noms alternatifs relatifs à LCK
LCK proto-oncogene, Src family tyrosine kinase (lck), LCK proto-oncogene, Src family tyrosine kinase (LCK), lymphocyte protein tyrosine kinase (Lck), LCK proto-oncogene, Src family tyrosine kinase (Lck), Hck-3, LCK, Lck1, Lcktkr, Lsk, LSK, Lskt, p56Protein level used designations for LCK
- lymphocyte protein tyrosine kinase
- lymphocyte-specific protein tyrosine kinase
- tyrosine-protein kinase Lck-like
- leukocyte C-terminal Src kinase
- lymphocyte cell-specific protein-tyrosine kinase
- proto-oncogene tyrosine-protein kinase LCK
- T-lymphocyte specific protein tyrosine kinase p56lck
- p56(LSTRA) protein-tyrosine kinase
- t cell-specific protein-tyrosine kinase
- tyrosine-protein kinase Lck
- tyrosine protein kinase
- tyrosine-protein kinase LCK
- p56-LCK
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