LCP2 Produits
(Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))
Catégories
SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008].
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Catégories LCP2 en vedette
LCP2 Anticorps
High quality antibodies with extensive validation data.
LCP2 Kits ELISA
Reliable ELISA kits for a wide range of species.
LCP2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
LCP2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Application
WB, IHC, ICC
Validations
- (4)
N° du produit
ABIN1859636
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
N° du produit
ABIN94501
Quantité
0.1 mg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (2)
N° du produit
ABIN3023382
Quantité
100 μL
Fiche technique
Fiche technique
LCP2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN5691942
Quantité
2 x 96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1141096
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1141097
Quantité
96 tests
Fiche technique
Fiche technique
LCP2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309248
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Baculovirus infected Insect Cells
Validations
- (1)
N° du produit
ABIN7281315
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN2115473
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits LCP2
: "Serum calcium-decreasing factor, caldecrin, inhibits receptor activator of NF-?B ligand (RANKL)-mediated Ca2+ signaling and actin ring formation in mature osteoclasts via suppression of Src signaling ..." dans: The Journal of biological chemistry, Vol. 287, Issue 22, pp. 17963-74, (2012) (PubMed).: "Cutting edge: the "death" adaptor CRADD/RAIDD targets BCL10 and suppresses agonist-induced cytokine expression in T lymphocytes." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 6, pp. 2493-7, (2012) (PubMed).
: "T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component." dans: The Journal of biological chemistry, Vol. 286, Issue 9, pp. 7535-47, (2011) (PubMed).
: "Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation." dans: The Journal of cell biology, Vol. 195, Issue 5, pp. 839-53, (2011) (PubMed).
: "Dual role of SLP-76 in mediating T cell receptor-induced activation of phospholipase C-gamma1." dans: The Journal of biological chemistry, Vol. 282, Issue 5, pp. 2937-46, (2007) (PubMed).
: "SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 16, pp. 6638-43, (2007) (PubMed).
: "A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76." dans: The Journal of experimental medicine, Vol. 204, Issue 3, pp. 681-91, (2007) (PubMed).
: "SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond." dans: Nature reviews. Immunology, Vol. 6, Issue 1, pp. 67-78, (2006) (PubMed).
: "The SLP-76 family of adapter proteins." dans: Seminars in immunology, Vol. 16, Issue 6, pp. 379-93, (2004) (PubMed).
: "Adaptor proteins in lymphocyte activation." dans: Current opinion in immunology, Vol. 15, Issue 3, pp. 269-76, (2003) (PubMed).
Synonymes et noms alternatifs relatifs à LCP2
lymphocyte cytosolic protein 2 (Lcp2), lymphocyte cytosolic protein 2 (LCP2), AI323664, BB161688, SLP-76, SLP76, Slp76, twmProtein level used designations for LCP2
- SH2 domain-containing leukocyte protein of 76 kDa
- SLP-76 tyrosine phosphoprotein
- lymphocyte cytosolic protein 2 (SH2 domain-containing leukocyte protein of 76kD)
- 76 kDa tyrosine phosphoprotein
- SH2 domain-containing leukocyte protein of 76kD
- lymphocyte cytosolic protein 2
- tyrosine phosphoprotein slp-76
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