LGMN Produits
(Legumain (LGMN))
Catégories
This gene encodes a cysteine protease that has a strict specificity for hydrolysis of asparaginyl bonds. This enzyme may be involved in the processing of bacterial peptides and endogenous proteins for MHC class II presentation in the lysosomal/endosomal systems. Enzyme activation is triggered by acidic pH and appears to be autocatalytic. Protein expression occurs after monocytes differentiate into dendritic cells. A fully mature, active enzyme is produced following lipopolysaccharide expression in mature dendritic cells. Overexpression of this gene may be associated with the majority of solid tumor types. This gene has a pseudogene on chromosome 13. Several alternatively spliced transcript variants have been described, but the biological validity of only two has been determined. These two variants encode the same isoform. [provided by RefSeq, Jul 2008].
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Catégories LGMN en vedette
LGMN Anticorps
High quality antibodies with extensive validation data.
LGMN Kits ELISA
Reliable ELISA kits for a wide range of species.
LGMN Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
LGMN recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (8)
N° du produit
ABIN7435007
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (7)
N° du produit
ABIN7440881
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, FACS, IHC (p)
Validations
- (5)
N° du produit
ABIN750958
Quantité
100 μL
Fiche technique
Fiche technique
LGMN recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Cow
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968243
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6957427
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6957428
Quantité
96 tests
Fiche technique
Fiche technique
LGMN recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7275145
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN7275144
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309356
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits LGMN
: "Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease." dans: Nature communications, Vol. 6, pp. 8762, (2015) (PubMed).: "Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia." dans: Molecular and cellular biology, Vol. 35, Issue 9, pp. 1491-505, (2015) (PubMed).
: "Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage." dans: Cell research, Vol. 24, Issue 3, pp. 344-58, (2014) (PubMed).
: "Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment." dans: Nature communications, Vol. 5, pp. 4280, (2014) (PubMed).
: "Degradation of acetoacetyl-CoA synthetase, a ketone body-utilizing enzyme, by legumain in the mouse kidney." dans: Biochemical and biophysical research communications, Vol. 453, Issue 3, pp. 631-5, (2014) (PubMed).
: "Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease." dans: The Journal of biological chemistry, Vol. 288, Issue 24, pp. 17495-507, (2013) (PubMed).
: "Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 23, pp. 9053-8, (2012) (PubMed).
: "Targeting cell surface alpha(v)beta(3) integrin increases therapeutic efficacies of a legumain protease-activated auristatin prodrug." dans: Molecular pharmaceutics, Vol. 9, Issue 1, pp. 168-75, (2012) (PubMed).
: "Expression of the cysteine protease legumain in vascular lesions and functional implications in atherogenesis." dans: Atherosclerosis, Vol. 201, Issue 1, pp. 53-66, (2009) (PubMed).
: "Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase." dans: Molecular cell, Vol. 29, Issue 6, pp. 665-78, (2008) (PubMed).
Synonymes et noms alternatifs relatifs à LGMN
legumain (LGMN), legumain (Lgmn), legumain L homeolog (lgmn.L), legumain (lgmn), delta vacuolar processing enzyme (DELTA-VPE), legumain (MBOO_RS07785), Legumain (Odosp_3582), legumain (LOC569153), AEP, AI746452, AU022324, cb173, cb460, DELTA VACUOLAR PROCESSING ENZYME, delta vacuolar processing enzyme, DELTAVPE, lgmn, LGMN1, MGC64351, MGC88980, PRSC1, Prsc1, sb:cb173, wu:fa98g05, wu:fj92g08, zgc:76953Protein level used designations for LGMN
- asparaginyl endopeptidase
- cysteine protease 1
- protease, cysteine 1
- protease, cysteine, 1 (legumain)
- preprolegumain
- protease, cysteine, 1
- legumain
- Legumain
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