LIG4 Produits
(Ligase IV, DNA, ATP-Dependent (LIG4))
Catégories
The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008].
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Catégories LIG4 en vedette
LIG4 Anticorps
High quality antibodies with extensive validation data.
LIG4 Kits ELISA
Reliable ELISA kits for a wide range of species.
LIG4 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
LIG4 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
N° du produit
ABIN6262967
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (2)
- (3)
N° du produit
ABIN3022475
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (4)
N° du produit
ABIN2778272
Quantité
100 μL
Fiche technique
Fiche technique
LIG4 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6216177
Quantité
96 tests
Fiche technique
Fiche technique
LIG4 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309405
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3092165
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3136262
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits LIG4
: "TOP2β-Dependent Nuclear DNA Damage Shapes Extracellular Growth Factor Responses via Dynamic AKT Phosphorylation to Control Virus Latency." dans: Molecular cell, Vol. 74, Issue 3, pp. 466-480.e4, (2019) (PubMed).: "Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." dans: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." dans: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
: "Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining." dans: Nature cell biology, Vol. 19, Issue 1, pp. 68-75, (2017) (PubMed).
: "Protein phosphatase 1 and phosphatase 1 nuclear targeting subunit-dependent regulation of DNA-dependent protein kinase and non-homologous end joining." dans: Nucleic acids research, Vol. 45, Issue 18, pp. 10583-10594, (2017) (PubMed).
: "An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells." dans: PLoS ONE, Vol. 8, Issue 2, pp. e55493, (2013) (PubMed).
: "The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2." dans: Journal of virology, Vol. 86, Issue 5, pp. 2400-15, (2012) (PubMed).
: "The HTLV-1 Tax oncoprotein represses Ku80 gene expression." dans: Virology, Vol. 416, Issue 1-2, pp. 1-8, (2011) (PubMed).
Synonymes et noms alternatifs relatifs à LIG4
ligase IV, DNA, ATP-dependent (lig4), DNA ligase 4 (LIG4), DNA ligase 4 (LOC100212302), DNA ligase 4 (CpipJ_CPIJ005161), DNA ligase 4 (PTRG_09982), DNA ligase 4 (MCYG_05151), DNA ligase 4 (LOC657210), ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining (LIG4), DNA ligase IV (ATLIG4), ligase IV, DNA, ATP-dependent L homeolog (lig4.L), ligase IV, DNA, ATP-dependent (Lig4), DNA ligase 4 (Lig4), 5830471N16Rik, DNA LIGASE IV, DNL4, lig4, LIG4, lig4-A, tiny, zgc:165595Protein level used designations for LIG4
- DNA ligase 4
- ligase IV, DNA, ATP-dependent
- DNA ligase IV
- DNA ligase (ATP) 4
- GLEAN_12219
- ligase4-like protein
- DNA ligase 4-like
- dsDNA break repair ligase
- polydeoxyribonucleotide synthase [ATP] 4
- DNA joinase
- DNA repair enzyme
- polynucleotide ligase
- sealase
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