LIN28A Produits
(Lin-28 Homolog A (C. Elegans) (LIN28A))
Catégories
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).
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Catégories LIN28A en vedette
LIN28A Anticorps
High quality antibodies with extensive validation data.
LIN28A Kits ELISA
Reliable ELISA kits for a wide range of species.
LIN28A Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
LIN28A recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB, IF, FACS, IHC (p)
Validations
- (6)
N° du produit
ABIN655156
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, ICC
Validations
- (2)
- (3)
N° du produit
ABIN968936
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Human, Pig, Sheep
Application
WB, IHC, IHC (p)
Validations
- (4)
N° du produit
ABIN6741558
Quantité
100 μL
Fiche technique
Fiche technique
LIN28A recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968296
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6957482
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6957483
Quantité
96 tests
Fiche technique
Fiche technique
LIN28A recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7123766
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN667750
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1309449
Quantité
25 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits LIN28A
: "Cancer stem-like cells can be induced through dedifferentiation under hypoxic conditions in glioma, hepatoma and lung cancer." dans: Cell death discovery, Vol. 3, pp. 16105, (2017) (PubMed).: "A Rapid Induction Mechanism for Lin28a in Trophic Responses." dans: Molecular cell, Vol. 65, Issue 3, pp. 490-503.e7, (2017) (PubMed).
: "Organoid models of human and mouse ductal pancreatic cancer. ..." dans: Cell, Vol. 160, Issue 1-2, pp. 324-38, (2015) (PubMed).
: "Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells." dans: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 232, Issue 2, pp. 487-97, (2005) (PubMed).
: "Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells." dans: Molecular and cellular biology, Vol. 25, Issue 21, pp. 9198-208, (2005) (PubMed).
Synonymes et noms alternatifs relatifs à LIN28A
lin-28 homolog A (LIN28A), lin-28 homolog A (C. elegans) (Lin28a), lin-28 homolog A S homeolog (lin28a.S), lin-28 homolog A (C. elegans) (lin28a), lin-28 homolog A (Lin28a), lin-28 homolog A (lin28a), AL024421, CSDD1, csdd1, ENSMUSG00000070700, Gm10299, LIN-28, Lin-28, lin-28, lin-28A, LIN28, Lin28, lin28, RGD1566408, sb:cb650, Tex17, ZCCHC1, zcchc1, zgc:55584Protein level used designations for LIN28A
- RNA-binding protein LIN-28
- protein lin-28 homolog A
- zinc finger CCHC domain-containing protein 1
- zinc finger, CCHC domain containing 1
- testis expressed gene 17
- testis-expressed protein 17
- RNA-binding protein LIN-28A
- lin-28A
- RNA-binding protein lin-28
- Lin-28.1
- lin-28 homolog A (C. elegans)
- lin-28-like
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