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LITAF Produits

(Lipopolysaccharide-Induced Tumor Necrosis Factor-alpha Factor (LITAF))

Catégories

Lipopolysaccharide is a potent stimulator of monocytes and macrophages, causing secretion of tumor necrosis factor-alpha (TNF-alpha) and other inflammatory mediators. This gene encodes lipopolysaccharide-induced TNF-alpha factor, which is a DNA-binding protein and can mediate the TNF-alpha expression by direct binding to the promoter region of the TNF-alpha gene. The transcription of this gene is induced by tumor suppresor p53 and has been implicated in the p53-induced apoptotic pathway. Mutations in this gene cause Charcot-Marie-Tooth disease type 1C (CMT1C) and may be involved in the carcinogenesis of extramammary Paget's disease (EMPD). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2008].

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Catégories LITAF en vedette

LITAF Anticorps

High quality antibodies with extensive validation data.

LITAF Kits ELISA

Reliable ELISA kits for a wide range of species.

LITAF Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

LITAF recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IF, IHC (p)
Validations
  • (4)
N° du produit ABIN523000
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
N° du produit ABIN7158438
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (3)
N° du produit ABIN7074508
Quantité 100 μL
Fiche technique Fiche technique

LITAF recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Chicken
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN5593872
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1140821
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1140824
Quantité 96 tests
Fiche technique Fiche technique

LITAF recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123779
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN1098763
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1309476
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits LITAF

Zhu, Guariglia, Yu, Li, Brancho, Peinado, Lyden, Salzer, Bennett, Chow: "Mutation of SIMPLE in Charcot-Marie-Tooth 1C alters production of exosomes." dans: Molecular biology of the cell, Vol. 24, Issue 11, pp. 1619-37, S1-3, (2013) (PubMed).

Tang, Metzger, Leeman, Amar: "LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 37, pp. 13777-82, (2006) (PubMed).

Saifi, Szigeti, Wiszniewski, Shy, Krajewski, Hausmanowa-Petrusewicz, Kochanski, Reeser, Mancias, Butler, Lupski: "SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation." dans: Human mutation, Vol. 25, Issue 4, pp. 372-83, (2005) (PubMed).

Moriwaki, Begum, Kobayashi, Matsumoto, Toyoshima, Seya: "Mycobacterium bovis Bacillus Calmette-Guerin and its cell wall complex induce a novel lysosomal membrane protein, SIMPLE, that bridges the missing link between lipopolysaccharide and p53-inducible gene, LITAF(PIG7), and estrogen-inducible gene, EET-1." dans: The Journal of biological chemistry, Vol. 276, Issue 25, pp. 23065-76, (2001) (PubMed).

Myokai, Takashiba, Lebo, Amar: "A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4518-23, (1999) (PubMed).

Synonymes et noms alternatifs relatifs à LITAF

lipopolysaccharide induced TNF factor (LITAF), lipopolysaccharide-induced TNF factor (Litaf), LPS-induced TN factor (Litaf), 3222402J11Rik, C85531, EET-1, N4WBP3, PIG7, Pig7, SIMPLE, TBX1, TNF-alpha, TP53I7

Protein level used designations for LITAF

  • LPS-induced TNF-alpha factor
  • lipopolysaccharide-induced TNF-alpha factor
  • lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • p53-induced gene 7 protein
  • small integral membrane protein of lysosome/late endosome
  • tumor protein p53 inducible protein 7
  • LPS-induced TN factor
  • LPS-induced TNF-alpha factor homolog
  • estrogen-enhanced transcript protein 1
  • estrogen-responsive uterine transcript
  • lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog
  • TNF-alpha factor
  • lipid-induced TNF-alpha factor
  • tissue necrosis factor-alpha
  • LITAF-like protein
  • Nedd4 WW domain-binding protein 3
  • estrogen-enhanced transcript protein
  • mEET
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