LRP2 Produits
(Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))
Catégories
The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling\; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).[provided by RefSeq, Aug 2009].
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Catégories LRP2 en vedette
LRP2 Anticorps
High quality antibodies with extensive validation data.
LRP2 Kits ELISA
Reliable ELISA kits for a wide range of species.
LRP2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
LRP2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
FACS, IF (cc), IF (p)
Validations
- (1)
N° du produit
ABIN750991
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
ELISA, FACS, IF (cc), IF (p), IHC (p), ICC, IHC (fro)
Validations
- (2)
- (4)
N° du produit
ABIN750988
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC, IF
Validations
- (3)
N° du produit
ABIN7158571
Quantité
100 μg
Fiche technique
Fiche technique
LRP2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968352
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968350
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6999575
Quantité
96 tests
Fiche technique
Fiche technique
LRP2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7397174
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Yeast
Validations
- (1)
N° du produit
ABIN5713618
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits LRP2
: "Effects of ATRAP in Renal Proximal Tubules on Angiotensin-Dependent Hypertension." dans: Journal of the American Heart Association, Vol. 8, Issue 8, pp. e012395, (2019) (PubMed).: "IL-6/Smad2 signaling mediates acute kidney injury and regeneration in a murine model of neonatal hyperoxia." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 33, Issue 5, pp. 5887-5902, (2019) (PubMed).
: "Cadmium Complexed with β2-Microglubulin, Albumin and Lipocalin-2 rather than Metallothionein Cause Megalin:Cubilin Dependent Toxicity of the Renal Proximal Tubule." dans: International journal of molecular sciences, Vol. 20, Issue 10, (2019) (PubMed).
: "A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells." dans: Stem cell reports, Vol. 11, Issue 2, pp. 470-484, (2018) (PubMed).
: "Combined Structural and Functional Imaging of the Kidney Reveals Major Axial Differences in Proximal Tubule Endocytosis." dans: Journal of the American Society of Nephrology : JASN, Vol. 29, Issue 11, pp. 2696-2712, (2018) (PubMed).
: "Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism." dans: Cellular and molecular life sciences : CMLS, Vol. 75, Issue 21, pp. 4021-4040, (2018) (PubMed).
: "Human extravillous trophoblasts bind but do not internalize antiphospholipid antibodies." dans: Placenta, Vol. 42, pp. 9-16, (2016) (PubMed).
: "Role of serotonin in the regulation of renal proximal tubular epithelial cells." dans: Renal failure, Vol. 38, Issue 7, pp. 1141-50, (2016) (PubMed).
: "Rho GAP myosin IXa is a regulator of kidney tubule function." dans: American journal of physiology. Renal physiology, Vol. 309, Issue 6, pp. F501-13, (2015) (PubMed).
: "Aberrant differentiation of Tsc2-deficient teratomas associated with activation of the mTORC1-TFE3 pathway." dans: Oncology reports, Vol. 34, Issue 5, pp. 2251-8, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à LRP2
LDL receptor related protein 2 (LRP2), low density lipoprotein receptor-related protein 2a (lrp2a), low density lipoprotein receptor-related protein 2 (LRP2), low-density lipoprotein receptor-related protein 2 (LRP2.3), LDL receptor related protein 2 L homeolog (lrp2.L), low-density lipoprotein receptor-related protein 2 (LOC100183506), LDL receptor related protein 2 (lrp2), low density lipoprotein receptor-related protein 2 (Lrp2), LDL receptor related protein 2 (Lrp2), AI315343, AW536255, D230004K18Rik, dbs, DBS, gp330, GP330, Gp330, im:680590, lrp2, megalin, MegalinProtein level used designations for LRP2
- low density lipoprotein-related protein 2
- gp330b
- low-density lipoprotein receptor-related protein 2
- megalin
- low density lipoprotein receptor-related protein 2
- low-density lipoprotein receptor-related protein 2-like
- Heymann nephritis antigen homolog
- LRP-2
- calcium sensor protein
- glycoprotein 330
- gp330
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