MAP3K4 Produits
(Mitogen-Activated Protein Kinase Kinase Kinase 4 (MAP3K4))
Catégories
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].
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Catégories MAP3K4 en vedette
MAP3K4 Anticorps
High quality antibodies with extensive validation data.
MAP3K4 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MAP3K4 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, WB, IHC (p)
Validations
- (4)
N° du produit
ABIN561801
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
IHC, WB
Validations
- (4)
N° du produit
ABIN7268654
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, WB, PLA
Validations
- (3)
N° du produit
ABIN561800
Quantité
100 μg
Fiche technique
Fiche technique
MAP3K4 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6219424
Quantité
96 tests
Fiche technique
Fiche technique
MAP3K4 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310218
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN2750508
Quantité
5 applications
Fiche technique
Fiche technique
Dernières publications sur nos produits MAP3K4
: "The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms." dans: The Journal of biological chemistry, Vol. 279, Issue 38, pp. 39366-73, (2004) (PubMed).: "Axin utilizes distinct regions for competitive MEKK1 and MEKK4 binding and JNK activation." dans: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37451-8, (2003) (PubMed).
: "Oligomerization of human Gadd45a protein." dans: The Journal of biological chemistry, Vol. 276, Issue 42, pp. 39330-9, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à MAP3K4
mitogen activated protein kinase kinase kinase 4 (Map3k4), mitogen-activated protein kinase kinase kinase 4 (MAP3K4), mitogen-activated protein kinase kinase kinase 4 (Map3k4), D17Rp17, D17Rp17e, MAPKKK4, Mek4b, MEKK4, MEKK 4, Mekk4, mKIAA0213, MTK1, PRO0412, RP17, Rp17a, TasProtein level used designations for MAP3K4
- mitogen-activated protein kinase kinase kinase 4
- MAP three kinase 1
- MAP/ERK kinase kinase 4
- MAPK/ERK kinase kinase 4
- MEK kinase 4
- MEKK 4
- SSK2/SSK22 MAP kinase kinase kinase, yeast, homolog of
- dJ473J16.1 (mitogen-activated protein kinase kinase kinase 4)
- predicted protein of HQ0412
- T-associated sex reversal
- mitogen activated protein kinase kinase kinase 4
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