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MAP3K7 Produits

(Mitogen-Activated Protein Kinase Kinase Kinase 7 (MAP3K7))

Catégories

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2\; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

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Catégories MAP3K7 en vedette

MAP3K7 Anticorps

High quality antibodies with extensive validation data.

MAP3K7 Kits ELISA

Reliable ELISA kits for a wide range of species.

MAP3K7 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

MAP3K7 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (10)
N° du produit ABIN6256492
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (7)
N° du produit ABIN6143503
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IF, IP
Validations
  • (5)
N° du produit ABIN948522
Quantité 100 μL
Fiche technique Fiche technique

MAP3K7 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6957869
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1380474
Quantité 2 x 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1380773
Quantité 2 x 96 tests
Fiche technique Fiche technique

MAP3K7 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (3)
  • (1)
N° du produit ABIN1310225
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1310227
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3093681
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits MAP3K7

Huang, Chiang, Hung, Hou: "Targeting of TGF-β-activated protein kinase 1 inhibits chemokine (C-C motif) receptor 7 expression, tumor growth and metastasis in breast cancer." dans: Oncotarget, Vol. 6, Issue 2, pp. 995-1007, (2015) (PubMed).

Salazar, Kashiwada, Krejci, Meyer, Casale, Hallowell, Wilcox, Donoghue, Thompson: "Fibroblast growth factor receptor 3 interacts with and activates TGF?-activated kinase 1 tyrosine phosphorylation and NF?B signaling in multiple myeloma and bladder cancer." dans: PLoS ONE, Vol. 9, Issue 1, pp. e86470, (2014) (PubMed).

Lei, Han, Xiao, Jin, He, Wang: "Enterovirus 71 3C inhibits cytokine expression through cleavage of the TAK1/TAB1/TAB2/TAB3 complex." dans: Journal of virology, Vol. 88, Issue 17, pp. 9830-41, (2014) (PubMed).

Sorrentino, Thakur, Grimsby, Marcusson, von Bulow, Schuster, Zhang, Heldin, Landström: "The type I TGF-beta receptor engages TRAF6 to activate TAK1 in a receptor kinase-independent manner." dans: Nature cell biology, Vol. 10, Issue 10, pp. 1199-207, (2008) (PubMed).

Liu, Yao, Li, Wang, Zheng, Cao: "CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages." dans: Blood, Vol. 112, Issue 13, pp. 4961-70, (2008) (PubMed).

Ahn, Rong, Kroll, Van Meir, Snyder, Ye: "PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion." dans: The Journal of biological chemistry, Vol. 279, Issue 16, pp. 16441-51, (2004) (PubMed).

Smit, Baas, Kuipers, Korswagen, van de Wetering, Clevers: "Wnt activates the Tak1/Nemo-like kinase pathway." dans: The Journal of biological chemistry, Vol. 279, Issue 17, pp. 17232-40, (2004) (PubMed).

Akira, Takeda: "Toll-like receptor signalling." dans: Nature reviews. Immunology, Vol. 4, Issue 7, pp. 499-511, (2004) (PubMed).

Ono, Ohtomo, Ninomiya-Tsuji, Tsuchiya: "A dominant negative TAK1 inhibits cellular fibrotic responses induced by TGF-beta." dans: Biochemical and biophysical research communications, Vol. 307, Issue 2, pp. 332-7, (2003) (PubMed).

Sakurai, Suzuki, Kawasaki, Nakano, Okazaki, Chino, Doi, Saiki: "Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway." dans: The Journal of biological chemistry, Vol. 278, Issue 38, pp. 36916-23, (2003) (PubMed).

Synonymes et noms alternatifs relatifs à MAP3K7

mitogen-activated protein kinase kinase kinase 7 (map3k7), mitogen activated protein kinase kinase kinase 7 (Map3k7), mitogen-activated protein kinase kinase kinase 7 (MAP3K7), mitogen-activated protein kinase kinase kinase 7 (Map3k7), B430101B05, C87327, MEKK7, si:ch211-225h9.1, Tak1, TAK1, TGF1a, zgc:110612

Protein level used designations for MAP3K7

  • mitogen-activated protein kinase kinase kinase 7
  • tak1
  • TGF-beta-activated kinase TAK1
  • TGF-beta activated kinase 1
  • TGF-beta-activated kinase 1
  • transforming growth factor-beta-activated kinase 1
  • mitogen activated protein kinase kinase kinase 7
  • transforming growth factor beta-activated kinase 1
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