MAP3K9 Produits
(Mitogen-Activated Protein Kinase Kinase Kinase 9 (MAP3K9))
Catégories
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
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Catégories MAP3K9 en vedette
MAP3K9 Anticorps
High quality antibodies with extensive validation data.
MAP3K9 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MAP3K9 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Rat
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (4)
N° du produit
ABIN872294
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
N° du produit
ABIN7160061
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
- (2)
N° du produit
ABIN392422
Quantité
400 μL
Fiche technique
Fiche technique
MAP3K9 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310241
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5509016
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3093690
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits MAP3K9
: "Ablation of mixed lineage kinase 3 (Mlk3) does not inhibit ototoxicity induced by acoustic trauma or aminoglycoside exposure." dans: Hearing research, Vol. 270, Issue 1-2, pp. 21-7, (2011) (PubMed).: "Mixed lineage kinase-3 stabilizes and functionally cooperates with TRIBBLES-3 to compromise mitochondrial integrity in cytokine-induced death of pancreatic beta cells." dans: The Journal of biological chemistry, Vol. 285, Issue 29, pp. 22426-36, (2010) (PubMed).
: "Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation." dans: BMC genomics, Vol. 10, pp. 67, (2009) (PubMed).
: "Phosphoregulation of mixed-lineage kinase 1 activity by multiple phosphorylation in the activation loop." dans: Biochemistry, Vol. 43, Issue 51, pp. 16348-55, (2004) (PubMed).
: "Akt2 negatively regulates assembly of the POSH-MLK-JNK signaling complex." dans: The Journal of biological chemistry, Vol. 278, Issue 48, pp. 47922-7, (2003) (PubMed).
: "The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis." dans: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4713-24, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à MAP3K9
mitogen-activated protein kinase kinase kinase 9 (MAP3K9), mitogen-activated protein kinase kinase kinase 9 (Map3k9), E130314H24Rik, MEKK9, MLK1, Mlk1, PRKE1, Prke1, RGD1562149Protein level used designations for MAP3K9
- mixed lineage kinase 1 (tyr and ser/thr specificity)
- mitogen activated protein kinase kinase kinase 9
- mixed-lineage kinase 1
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