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MASP1 Produits

(Mannan-Binding Lectin Serine Peptidase 1 (MASP1))

Catégories

This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].

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Catégories MASP1 en vedette

MASP1 Anticorps

High quality antibodies with extensive validation data.

MASP1 Kits ELISA

Reliable ELISA kits for a wide range of species.

MASP1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

MASP1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
  • (6)
N° du produit ABIN7434299
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7434302
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF (p), IHC (p)
Validations
  • (2)
N° du produit ABIN733508
Quantité 100 μL
Fiche technique Fiche technique

MASP1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (3)
  • (1)
N° du produit ABIN6957634
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6957635
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6968437
Quantité 96 tests
Fiche technique Fiche technique

MASP1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1310414
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7505079
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
N° du produit ABIN7454178
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits MASP1

Wang, Liu, Ye, Jiang, Yu, Xu, Du, Ma, Cao, Yuan, Shen, Lin, Zhang, Li: "Plasma proteome profiling of high-altitude polycythemia using TMT-based quantitative proteomics approach." dans: Journal of proteomics, Vol. 194, pp. 60-69, (2020) (PubMed).

Klassert, Goyal, Stock, Driesch, Hussain, Berrocal-Almanza, Myakala, Sumanlatha, Valluri, Ahmed, Schumann, Flores, Slevogt: "AmpliSeq Screening of Genes Encoding the C-Type Lectin Receptors and Their Signaling Components Reveals a Common Variant in MASP1 Associated with Pulmonary Tuberculosis in an Indian Population." dans: Frontiers in immunology, Vol. 9, pp. 242, (2019) (PubMed).

Kasanmoentalib, Valls Seron, Ferwerda, Tanck, Zwinderman, Baas, van der Ende, Brouwer, van de Beek: "Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis." dans: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 2, (2017) (PubMed).

Hansen, Csuka, Munthe-Fog, Varga, Farkas, Hansen, Koch, Skjødt, Garred, Skjoedt: "The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 8, pp. 3596-604, (2015) (PubMed).

Radu, Hu, Jiang, Bok: "Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype." dans: The Journal of biological chemistry, Vol. 289, Issue 13, pp. 9113-20, (2014) (PubMed).

Hajela, Kojima, Ambrus, Wong, Moffatt, Ferluga, Hajela, Gál, Sim: "The biological functions of MBL-associated serine proteases (MASPs)." dans: Immunobiology, Vol. 205, Issue 4-5, pp. 467-75, (2002) (PubMed).

Endo, Takahashi, Kuraya, Matsushita, Stover, Schwaeble, Fujita: "Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter." dans: International immunology, Vol. 14, Issue 10, pp. 1193-201, (2002) (PubMed).

Kuraya, Matsushita, Endo, Thiel, Fujita: "Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G." dans: International immunology, Vol. 15, Issue 1, pp. 109-17, (2002) (PubMed).

Schwaeble, Dahl, Thiel, Stover, Jensenius: "The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes." dans: Immunobiology, Vol. 205, Issue 4-5, pp. 455-66, (2002) (PubMed).

Matsushita, Kuraya, Hamasaki, Tsujimura, Shiraki, Fujita: "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 7, pp. 3502-6, (2002) (PubMed).

Synonymes et noms alternatifs relatifs à MASP1

mannan-binding lectin serine peptidase 1 (Masp1), mannan binding lectin serine peptidase 1 (MASP1), 3MC1, AW048060, CCPII, Crarf, CRARF, CRARF1, MAP1, MAp44, MASP, Masp1/3, MASP3, PRSS5, RaRF

Protein level used designations for MASP1

  • MASP-1
  • complement factor MASP-3
  • complement-activating component of Ra-reactive factor
  • mannan-binding lectin serine protease 1
  • mannose-binding lectin-associated serine protease 1
  • mannose-binding protein-associated serine protease
  • ra-reactive factor serine protease p100
  • raRF
  • serine protease 5
  • Ra-reactive factor serine protease p100
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