MASP1 Produits
(Mannan-Binding Lectin Serine Peptidase 1 (MASP1))
Catégories
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010].
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Catégories MASP1 en vedette
MASP1 Anticorps
High quality antibodies with extensive validation data.
MASP1 Kits ELISA
Reliable ELISA kits for a wide range of species.
MASP1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
MASP1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, ICC, IHC (p), IHC (fro)
Validations
- (6)
N° du produit
ABIN7434299
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (4)
N° du produit
ABIN7434302
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (p), IHC (p)
Validations
- (2)
N° du produit
ABIN733508
Quantité
100 μL
Fiche technique
Fiche technique
MASP1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
N° du produit
ABIN6957634
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6957635
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6968437
Quantité
96 tests
Fiche technique
Fiche technique
MASP1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310414
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7505079
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
N° du produit
ABIN7454178
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits MASP1
: "Plasma proteome profiling of high-altitude polycythemia using TMT-based quantitative proteomics approach." dans: Journal of proteomics, Vol. 194, pp. 60-69, (2020) (PubMed).: "AmpliSeq Screening of Genes Encoding the C-Type Lectin Receptors and Their Signaling Components Reveals a Common Variant in MASP1 Associated with Pulmonary Tuberculosis in an Indian Population." dans: Frontiers in immunology, Vol. 9, pp. 242, (2019) (PubMed).
: "Mannose-binding lectin-associated serine protease 2 (MASP-2) contributes to poor disease outcome in humans and mice with pneumococcal meningitis." dans: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 2, (2017) (PubMed).
: "The Levels of the Lectin Pathway Serine Protease MASP-1 and Its Complex Formation with C1 Inhibitor Are Linked to the Severity of Hereditary Angioedema." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 8, pp. 3596-604, (2015) (PubMed).
: "Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype." dans: The Journal of biological chemistry, Vol. 289, Issue 13, pp. 9113-20, (2014) (PubMed).
: "The biological functions of MBL-associated serine proteases (MASPs)." dans: Immunobiology, Vol. 205, Issue 4-5, pp. 467-75, (2002) (PubMed).
: "Functional characterization of human mannose-binding lectin-associated serine protease (MASP)-1/3 and MASP-2 promoters, and comparison with the C1s promoter." dans: International immunology, Vol. 14, Issue 10, pp. 1193-201, (2002) (PubMed).
: "Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G." dans: International immunology, Vol. 15, Issue 1, pp. 109-17, (2002) (PubMed).
: "The mannan-binding lectin-associated serine proteases (MASPs) and MAp19: four components of the lectin pathway activation complex encoded by two genes." dans: Immunobiology, Vol. 205, Issue 4-5, pp. 455-66, (2002) (PubMed).
: "Activation of the lectin complement pathway by H-ficolin (Hakata antigen)." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 7, pp. 3502-6, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à MASP1
mannan-binding lectin serine peptidase 1 (Masp1), mannan binding lectin serine peptidase 1 (MASP1), 3MC1, AW048060, CCPII, Crarf, CRARF, CRARF1, MAP1, MAp44, MASP, Masp1/3, MASP3, PRSS5, RaRFProtein level used designations for MASP1
- MASP-1
- complement factor MASP-3
- complement-activating component of Ra-reactive factor
- mannan-binding lectin serine protease 1
- mannose-binding lectin-associated serine protease 1
- mannose-binding protein-associated serine protease
- ra-reactive factor serine protease p100
- raRF
- serine protease 5
- Ra-reactive factor serine protease p100
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