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MBD4 Produits

(Methyl-CpG Binding Domain Protein 4 (MBD4))

Catégories

The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains an MBD domain at the N-terminus that functions both in binding to methylated DNA and in protein interactions and a C-terminal mismatch-specific glycosylase domain that is involved in DNA repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013].

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Catégories MBD4 en vedette

MBD4 Anticorps

High quality antibodies with extensive validation data.

MBD4 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

MBD4 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB
Validations
  • (3)
  • (1)
N° du produit ABIN1881532
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Rat
Application WB
Validations
  • (2)
N° du produit ABIN3044062
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Guinea Pig, Human
Application WB, ChIP
Validations
  • (2)
N° du produit ABIN2776028
Quantité 100 μL
Fiche technique Fiche technique

MBD4 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6224403
Quantité 96 tests
Fiche technique Fiche technique

MBD4 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7123938
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1310474
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1310473
Quantité 25 μg
Fiche technique Fiche technique

Dernières publications sur nos produits MBD4

Kristensen, Nielsen, Jørgensen, Skakkebæk, Rajpert-De Meyts, Almstrup: "Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis." dans: British journal of cancer, Vol. 110, Issue 3, pp. 668-78, (2014) (PubMed).

Arora, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Thyagarajan: "Polymorphisms in the base excision repair pathway and graft-versus-host disease." dans: Leukemia, Vol. 24, Issue 8, pp. 1470-5, (2010) (PubMed).

Thyagarajan, Lindgren, Basu, Nagaraj, Gross, Weisdorf, Arora: "Association between genetic variants in the base excision repair pathway and outcomes after hematopoietic cell transplantations." dans: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, Vol. 16, Issue 8, pp. 1084-9, (2010) (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." dans: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

Ruddock-DCruz, Xue, Wilson, Heffernan, Prashadkumar, Cooney, Sanchez-Partida, French, Holland: "Dynamic changes in the localization of five members of the methyl binding domain (MBD) gene family during murine and bovine preimplantation embryo development." dans: Molecular reproduction and development, Vol. 75, Issue 1, pp. 48-59, (2007) (PubMed).

Thatcher, Peddada, Yasui, Lasalle: "Homologous pairing of 15q11-13 imprinted domains in brain is developmentally regulated but deficient in Rett and autism samples." dans: Human molecular genetics, Vol. 14, Issue 6, pp. 785-97, (2005) (PubMed).

Synonymes et noms alternatifs relatifs à MBD4

methyl-CpG binding domain 4, DNA glycosylase (MBD4), methyl-CpG binding domain protein 4 (Mbd4), methyl-CpG binding domain 4 DNA glycosylase (Mbd4), MED1, Med1

Protein level used designations for MBD4

  • 3,N(4)-ethenocytosine glycosylase
  • G/5-fluorouracil mismatch glycosylase with biphasic kinetics
  • G/T mismatch glycosylase
  • G/U mismatch glycosylase
  • methyl-CpG-binding domain protein 4
  • methyl-CpG-binding endonuclease 1
  • methyl-CpG-binding protein MBD4
  • mismatch-specific DNA N-glycosylase
  • putative methyl-CpG binding protein
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