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MCM8 Produits

(Minichromosome Maintenance Deficient 8 (MCM8))

Catégories

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the MCM proteins. This protein has been shown to co-immunoprecipitate with MCM4, 6 and 7, which suggests that it may interact with other MCM proteins and play a role in DNA replication. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008].

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Catégories MCM8 en vedette

MCM8 Anticorps

High quality antibodies with extensive validation data.

MCM8 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

MCM8 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB, IHC
Validations
  • (1)
  • (3)
N° du produit ABIN309831
Quantité 25 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (2)
N° du produit ABIN529702
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Bat, Cow, Guinea Pig, Hamster, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application WB, IHC, IHC (p)
Validations
  • (2)
N° du produit ABIN6737804
Quantité 100 μL
Fiche technique Fiche technique

MCM8 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6211736
Quantité 96 tests
Fiche technique Fiche technique

MCM8 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1310565
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1990369
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7505291
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits MCM8

Inano, Sato, Katsuki, Kobayashi, Tanaka, Nakajima, Nakada, Miyoshi, Knies, Takaori-Kondo, Schindler, Ishiai, Kurumizaka, Takata: "RFWD3-Mediated Ubiquitination Promotes Timely Removal of Both RPA and RAD51 from DNA Damage Sites to Facilitate Homologous Recombination." dans: Molecular cell, Vol. 66, Issue 5, pp. 622-634.e8, (2017) (PubMed).

Park, Long, Lee, Abbas, Shibata, Negishi, Luo, Schimenti, Gambus, Walter, Dutta: "The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination." dans: Molecular and cellular biology, Vol. 33, Issue 8, pp. 1632-44, (2013) (PubMed).

Henderson, Hall, Prpic, Hessling, Parker, Sampson, Simkins, Brough, Dixon, Lenz, Knapp, Murphy, Taylor, Fischer, Malinowski: "The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia." dans: Journal of immunological methods, Vol. 370, Issue 1-2, pp. 1-13, (2011) (PubMed).

Ono, Kumai, Koizumi, Nishikawa, Kobayashi, Tadokoro: "Overexpression of heat shock protein 27 in squamous cell carcinoma of the uterine cervix: a proteomic analysis using archival formalin-fixed, paraffin-embedded tissues." dans: Human pathology, Vol. 40, Issue 1, pp. 41-9, (2008) (PubMed).

Synonymes et noms alternatifs relatifs à MCM8

minichromosome maintenance 8 homologous recombination repair factor (MCM8), minichromosome maintenance 8 homologous recombination repair factor (Mcm8), minichromosome maintenance 8 homologous recombination repair factor L homeolog (mcm8.L), 5730432L01Rik, C20orf154, dJ967N21.5

Protein level used designations for MCM8

  • DNA helicase MCM8
  • DNA replication licensing factor MCM8
  • MCM8 minichromosome maintenance deficient 8
  • REC homolog
  • minichromosome maintenance 8
  • minichromosome maintenance deficient 8
  • Minichromosome maintenance 8
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