MED12 Produits
(Mediator Complex Subunit 12 (MED12))
Catégories
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009].
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Catégories MED12 en vedette
MED12 Anticorps
High quality antibodies with extensive validation data.
MED12 Kits ELISA
Reliable ELISA kits for a wide range of species.
MED12 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (4)
N° du produit
ABIN6242936
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7159104
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7243679
Quantité
200 μL
Fiche technique
Fiche technique
MED12 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN1743269
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Sheep
Analytical Method
Validations
N° du produit
ABIN1774174
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN1744488
Quantité
96 tests
Fiche technique
Fiche technique
MED12 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310630
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits MED12
: "H19 lncRNA identified as a master regulator of genes that drive uterine leiomyomas." dans: Oncogene, Vol. 38, Issue 27, pp. 5356-5366, (2019) (PubMed).: "Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6." dans: Journal of medicinal chemistry, Vol. 59, Issue 19, pp. 9124-9139, (2016) (PubMed).
: "Sox10 cooperates with the mediator subunit 12 during terminal differentiation of myelinating glia." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 15, pp. 6679-90, (2013) (PubMed).
: "Temporal association of herpes simplex virus ICP4 with cellular complexes functioning at multiple steps in PolII transcription." dans: PLoS ONE, Vol. 8, Issue 10, pp. e78242, (2013) (PubMed).
: "Distinct alternative splicing patterns of mediator subunit genes during endothelial progenitor cell differentiation." dans: Biochimie, Vol. 94, Issue 8, pp. 1828-32, (2012) (PubMed).
: "Control of ground-state pluripotency by allelic regulation of Nanog." dans: Nature, Vol. 483, Issue 7390, pp. 470-3, (2012) (PubMed).
: "MED12 alterations in both human benign and malignant uterine soft tissue tumors." dans: PLoS ONE, Vol. 7, Issue 6, pp. e40015, (2012) (PubMed).
: "Epigenetic modifiers enhance the synergistic cytotoxicity of combined nucleoside analog-DNA alkylating agents in lymphoma cell lines." dans: Experimental hematology, Vol. 40, Issue 10, pp. 800-10, (2012) (PubMed).
: "A pituitary-specific enhancer of the POMC gene with preferential activity in corticotrope cells." dans: Molecular endocrinology (Baltimore, Md.), Vol. 25, Issue 2, pp. 348-59, (2011) (PubMed).
: "Core promoter recognition complex changes accompany liver development." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 10, pp. 3906-11, (2011) (PubMed).
Synonymes et noms alternatifs relatifs à MED12
mediator complex subunit 12 (MED12), mediator complex subunit 12 (Med12), mediator complex subunit 12 (med12), 230kDa, ARC240, CAGH45, FGS1, HOPA, MED12S, Mopa, OHDOX, OKS, OPA-1, OPA1, TNRC11, Tnrc11, TRAP230, Trap230Protein level used designations for MED12
- CAG repeat protein 45
- OPA-containing protein
- activator-recruited cofactor 240 kDa component
- human opposite paired
- mediator of RNA polymerase II transcription subunit 12
- mediator of RNA polymerase II transcription, subunit 12 homolog
- putative mediator subunit 12
- thyroid hormone receptor-associated protein complex 230 kDa component
- thyroid hormone receptor-associated protein, 230 kDa subunit
- trinucleotide repeat containing 11 (THR-associated protein, 230 kDa subunit)
- trinucleotide repeat-containing gene 11 protein
- trinucleotide repeat containing 11
- OPA-containing protein 1
- mediator complex subunit 12
- trinucleotide repeat containing 11 (THR-associated protein)
- kohtalo
- kto
- mot_m807
- motionless
- protein kohtalo
- protein motionless
- shiri
- shr
- thyroid hormone receptor-associated protein 230
- thyroid hormone receptor-associated protein complex component TRAP230
- trap230
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