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Metabotropic Glutamate Receptor 1 Produits

(Glutamate Receptor, Metabotropic 1 (GRM1))
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms\; some of which may have distinct functions. [provided by RefSeq, Jul 2008].

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Catégories Metabotropic Glutamate Receptor 1 en vedette

Metabotropic Glutamate Receptor 1 Anticorps

High quality antibodies with extensive validation data.

Metabotropic Glutamate Receptor 1 Kits ELISA

Reliable ELISA kits for a wide range of species.

Metabotropic Glutamate Receptor 1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

Metabotropic Glutamate Receptor 1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (4)
N° du produit ABIN7441226
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ICC, IP, IF, FACS, LCI
Validations
  • (5)
N° du produit ABIN7043245
Quantité 25 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (3)
N° du produit ABIN7190883
Quantité 100 μL
Fiche technique Fiche technique

Metabotropic Glutamate Receptor 1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6956163
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN1743298
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Sheep
Analytical Method
Validations
N° du produit ABIN1774203
Quantité 96 tests
Fiche technique Fiche technique

Metabotropic Glutamate Receptor 1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1355775
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7407208
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Mammalian Cells
Validations
N° du produit ABIN7538301
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits Metabotropic Glutamate Receptor 1

Tang, Liu, Xu, Zhang, Zhang, Zhou, Huang: "Interaction between astrocytic colony stimulating factor and its receptor on microglia mediates central sensitization and behavioral hypersensitivity in chronic post ischemic pain model." dans: Brain, behavior, and immunity, Vol. 68, pp. 248-260, (2019) (PubMed).

Li, Corbelli, Watanabe, Armelloni, Ikehata, Parazzi, Pignatari, Giardino, Mattinzoli, Lazzari, Puliti, Cellesi, Zennaro, Messa, Rastaldi: "Three-dimensional podocyte-endothelial cell co-cultures: Assembly, validation, and application to drug testing and intercellular signaling studies." dans: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Vol. 86, pp. 1-12, (2016) (PubMed).

Bovenschen, Spijkers, Wensink, Schellens, van Domselaar, van Baarle: "Elevated granzyme M-expressing lymphocytes during cytomegalovirus latency and reactivation after allogeneic stem cell transplantation." dans: Clinical immunology (Orlando, Fla.), Vol. 150, Issue 1, pp. 1-11, (2014) (PubMed).

Dobi, Sartori, Busti, Van der Putten, Singewald, Shigemoto, Ferraguti: "Neural substrates for the distinct effects of presynaptic group III metabotropic glutamate receptors on extinction of contextual fear conditioning in mice." dans: Neuropharmacology, Vol. 66, pp. 274-89, (2013) (PubMed).

Neves, Shah, Liodis, Achimastou, Denaxa, Roalfe, Sesay, Walker, Pachnis: "The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex." dans: Cerebral cortex (New York, N.Y. : 1991), Vol. 23, Issue 8, pp. 1811-23, (2013) (PubMed).

Coulon, Kanyshkova, Broicher, Munsch, Wettschureck, Seidenbecher, Meuth, Offermanns, Pape, Budde: "Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling." dans: Frontiers in cellular neuroscience, Vol. 4, pp. 132, (2011) (PubMed).

Hirdes, Napp, Wulfsen, Schweizer, Schwarz, Bauer: "Erg K+ currents modulate excitability in mouse mitral/tufted neurons." dans: Pflügers Archiv : European journal of physiology, Vol. 459, Issue 1, pp. 55-70, (2009) (PubMed).

Ferraguti, Crepaldi, Nicoletti: "Metabotropic glutamate 1 receptor: current concepts and perspectives." dans: Pharmacological reviews, Vol. 60, Issue 4, pp. 536-81, (2008) (PubMed).

Namkoong, Shin, Lee, Marín, Wall, Goydos, Chen: "Metabotropic glutamate receptor 1 and glutamate signaling in human melanoma." dans: Cancer research, Vol. 67, Issue 5, pp. 2298-305, (2007) (PubMed).

Crepaldi, Lackner, Corti, Ferraguti: "Transcriptional activators and repressors for the neuron-specific expression of a metabotropic glutamate receptor." dans: The Journal of biological chemistry, Vol. 282, Issue 24, pp. 17877-89, (2007) (PubMed).

Synonymes et noms alternatifs relatifs à Metabotropic Glutamate Receptor 1

glutamate metabotropic receptor 1 (GRM1), glutamate receptor, metabotropic 1a (grm1a), metabotropic glutamate receptor 1 (mGlutR1), glutamate receptor, metabotropic 1 (Grm1), glutamate receptor, metabotropic 1 (GRM1), 4930455H15Rik, ENSMUSG00000075319, fj39d05, GB18621, Glura, Gm10828, GPRC1A, Gprc1a, MGLU1, MGLUR1, mGluR1, mGlutR, nmf373, rcw, SCAR13, si:ch211-51a19.1, wobl, wu:fj39d05

Protein level used designations for Metabotropic Glutamate Receptor 1

  • metabotropic glutamate receptor 1
  • metabotropic glutamate receptor A
  • G protein coupled receptor, family C, group 1, member A
  • G protein-coupled receptor, family C, group 1, member A
  • G protein coupled receptor family C group 1 member A
  • mGluR1
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