Minichromosome Maintenance Deficient 4 Produits
(Minichromosome Maintenance Deficient 4 (MCM4))
Catégories
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008].
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Catégories Minichromosome Maintenance Deficient 4 en vedette
Minichromosome Maintenance Deficient 4 Anticorps
High quality antibodies with extensive validation data.
Minichromosome Maintenance Deficient 4 Kits ELISA
Reliable ELISA kits for a wide range of species.
Minichromosome Maintenance Deficient 4 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Minichromosome Maintenance Deficient 4 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IP
Validations
- (7)
N° du produit
ABIN950014
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p), IF
Validations
- (6)
N° du produit
ABIN517777
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, ELISA, IF
Validations
- (3)
N° du produit
ABIN7150334
Quantité
100 μg
Fiche technique
Fiche technique
Minichromosome Maintenance Deficient 4 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380406
Quantité
2 x 96 tests
Fiche technique
Fiche technique
Minichromosome Maintenance Deficient 4 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1310553
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1310555
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2725632
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Minichromosome Maintenance Deficient 4
: "Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells." dans: Nature, Vol. 512, Issue 7513, pp. 198-202, (2014) (PubMed).: "Cohesin acetylation promotes sister chromatid cohesion only in association with the replication machinery." dans: The Journal of biological chemistry, Vol. 287, Issue 41, pp. 34325-36, (2012) (PubMed).
: "The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia." dans: Journal of immunological methods, Vol. 370, Issue 1-2, pp. 1-13, (2011) (PubMed).
: "Reducing MCM levels in human primary T cells during the G(0)-->G(1) transition causes genomic instability during the first cell cycle." dans: Oncogene, Vol. 29, Issue 26, pp. 3803-14, (2010) (PubMed).
: "Expression, nuclear localization and interactions of human MCM/P1 proteins." dans: Biochemical and biophysical research communications, Vol. 236, Issue 1, pp. 118-25, (1997) (PubMed).
: "A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins." dans: European journal of biochemistry / FEBS, Vol. 230, Issue 3, pp. 1096-101, (1995) (PubMed).
: "The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins." dans: Nucleic acids research, Vol. 21, Issue 23, pp. 5289-93, (1994) (PubMed).
: "Fission yeast cdc21+ belongs to a family of proteins involved in an early step of chromosome replication." dans: Nucleic acids research, Vol. 20, Issue 21, pp. 5571-7, (1993) (PubMed).
: "A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication." dans: Nucleic acids research, Vol. 21, Issue 11, pp. 2541-7, (1993) (PubMed).
Synonymes et noms alternatifs relatifs à Minichromosome Maintenance Deficient 4
minichromosome maintenance complex component 4 L homeolog (mcm4.L), minichromosome maintenance complex component 4 S homeolog (mcm4.S), minichromosome maintenance complex component 4 (MCM4), minichromosome maintenance complex component 4 (mcm4), minichromosome maintenance complex component 4 (Mcm4), 19G, AI325074, AU045576, cb1025, cdc21, CDC21, Cdc21, CDC54, fc12c09, fj85g09, hCdc21, hm:zeh1616, mcdc21, Mcmd4, mKIAA4003, NKCD, NKGCD, P1-CDC21, wu:fc12c09, wu:fj85g09, zeh1616Protein level used designations for Minichromosome Maintenance Deficient 4
- DNA replication licensing factor mcm4-B
- xMCM4-B
- P1-CDC21-B
- CDC21 homolog-B
- minichromosome maintenance protein 4-B
- CDC21 homolog-A
- DNA replication licensing factor mcm4-A
- P1-CDC21-A
- minichromosome maintenance deficient 4
- minichromosome maintenance protein 4-A
- p98
- xMCM4-A
- CDC21 homolog
- DNA replication licensing factor MCM4
- homolog of S. pombe cell devision cycle 21
- MCM4 minichromosome maintenance deficient 4
- DNA replication licensing factor mcm4
- minichromosome maintenance protein 4
- P1-CDC21
- mini chromosome maintenance deficient 4 homolog
- minichromosome maintenance deficient 4 homolog
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- Mitogen-Activated Protein Kinase
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