NAE1 Produits
(NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))
Catégories
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Catégories NAE1 en vedette
NAE1 Anticorps
High quality antibodies with extensive validation data.
NAE1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
NAE1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (4)
N° du produit
ABIN563865
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
N° du produit
ABIN391418
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (2)
N° du produit
ABIN7161137
Quantité
100 μL
Fiche technique
Fiche technique
NAE1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1311928
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124126
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN2130748
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits NAE1
: "PPARγ neddylation essential for adipogenesis is a potential target for treating obesity." dans: Cell death and differentiation, Vol. 23, Issue 8, pp. 1296-311, (2016) (PubMed).: "More than the sum of its parts." dans: Cell reports, Vol. 1, Issue 1, pp. 1, (2012) (PubMed).
: "A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924." dans: Cell reports, Vol. 1, Issue 4, pp. 309-16, (2012) (PubMed).
: "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8." dans: Nature, Vol. 422, Issue 6929, pp. 330-4, (2003) (PubMed).
: "ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis." dans: Journal of neurochemistry, Vol. 85, Issue 3, pp. 801-9, (2003) (PubMed).
: "APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain." dans: The Journal of cell biology, Vol. 163, Issue 1, pp. 27-33, (2003) (PubMed).
: "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons." dans: The Journal of biological chemistry, Vol. 275, Issue 12, pp. 8929-35, (2000) (PubMed).
: "Covalent modification of all members of human cullin family proteins by NEDD8." dans: Oncogene, Vol. 18, Issue 48, pp. 6829-34, (2000) (PubMed).
: "APP-BP1, a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein." dans: The Journal of biological chemistry, Vol. 271, Issue 19, pp. 11339-46, (1996) (PubMed).
Synonymes et noms alternatifs relatifs à NAE1
beta-Amyloid precursor protein binding protein 1 (APP-BP1), NEDD8 activating enzyme E1 subunit 1 (NAE1), NEDD8 activating enzyme E1 subunit 1 (Nae1), NEDD8 activating enzyme E1 subunit 1 S homeolog (nae1.S), nedd8 activating enzyme E1 subunit 1 (nae1), NEDD8-activating enzyme E1 regulatory subunit (ula-1), 59kDa, A-116A10.1, anon-WO0140519.225, APPBP1, Appbp1, appbp1, CG7828, dAPP-BP1, dAPPBP1, Dmel\\CG7828, ula-1, zgc:66148Protein level used designations for NAE1
- APP-BP1-PA
- APP-BP1-PB
- CG7828-PA
- CG7828-PB
- APP-BP1
- NEDD8-activating enzyme E1 regulatory subunit
- NEDD8-activating enzyme E1 subunit
- amyloid beta precursor protein binding protein 1, 59kDa
- amyloid beta precursor protein-binding protein 1, 59 kDa
- amyloid beta precursor protein-binding protein 1, 59kD
- amyloid protein-binding protein 1
- proto-oncogene protein 1
- protooncogene protein 1
- APP-binding protein 1
- amyloid beta precursor protein binding protein 1
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