NEDD4 Produits
(Neural Precursor Cell Expressed, Developmentally Down-Regulated 4, E3 Ubiquitin Protein Ligase (NEDD4))
Catégories
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. Involved in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19193720). Predominantly involved in ubiquitination of membrane bound forms of ERBB4 rather than processed precursors and intermediate membrane-anchored 80 kDa fragments (m80HER4), with a lesser role in ubiquitination of ERBB4 intracellular domain E4ICD1 (PubMed:19047365). Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2 (By similarity).
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Catégories NEDD4 en vedette
NEDD4 Anticorps
High quality antibodies with extensive validation data.
NEDD4 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
NEDD4 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Application
WB, IHC, ELISA, FACS
Validations
- (5)
N° du produit
ABIN3031966
Quantité
0.4 mL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, FACS, IHC (p)
Validations
- (3)
N° du produit
ABIN653889
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC
Validations
- (3)
N° du produit
ABIN1681009
Quantité
100 μg
Fiche technique
Fiche technique
NEDD4 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6234773
Quantité
96 tests
Fiche technique
Fiche technique
NEDD4 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1312320
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3094038
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3134115
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits NEDD4
: "H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis." dans: Nature communications, Vol. 8, pp. 14799, (2017) (PubMed).: "p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN." dans: Cell death and differentiation, Vol. 21, Issue 1, pp. 146-60, (2013) (PubMed).
: "Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4." dans: The Journal of biological chemistry, Vol. 276, Issue 28, pp. 25990-6, (2001) (PubMed).
: "All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+." dans: The Journal of biological chemistry, Vol. 274, Issue 18, pp. 12525-30, (1999) (PubMed).
: "The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization." dans: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32329-36, (1998) (PubMed).
: "Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases." dans: The Journal of biological chemistry, Vol. 272, Issue 24, pp. 15085-92, (1997) (PubMed).
Synonymes et noms alternatifs relatifs à NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (NEDD4), neural precursor cell expressed, developmentally down-regulated 4 (Nedd4), CG42279 gene product from transcript CG42279-RJ (Nedd4), E3 ubiquitin-protein ligase Nedd-4 (LOC411723), E3 ubiquitin-protein ligase NEDD4 (LOC100457150), neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (nedd4), E3 ubiquitin-protein ligase NEDD4 (LOC100547485), neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase (Nedd4), AA959633, AL023035, AU019897, CG7555, CG32184, CG42279, Dmel\\CG42279, Dmel_CG7555, Dmel_CG32184, DNedd4, dNedd4, dNedd4-1, E430025J12Rik, GB16853, mKIAA0093, nedd4, NEDD4, Nedd4, NEDD4-1, Nedd4-1, Nedd4a, RPF1Protein level used designations for NEDD4
- E3 ubiquitin-protein ligase NEDD4
- NEDD-4
- cell proliferation-inducing gene 53 protein
- neural precursor cell expressed developmentally down-regulated protein 4
- receptor-potentiating factor 1
- neural precursor cell expressed, developmentally down-regulated gene 4
- neural precursor cell expressed, developmentally down-regulated gene 4a
- neural precursor cell expressed, developmentally down-regulted gene 4
- CG42279-PE
- CG42279-PF
- CG42279-PG
- CG42279-PH
- CG42279-PI
- CG42279-PJ
- CG42279-PK
- CG42279-PL
- CG42279-PM
- DNedd4
- Nedd4-PE
- Nedd4-PF
- Nedd4-PG
- Nedd4-PH
- Nedd4-PI
- Nedd4-PJ
- Nedd4-PK
- Nedd4-PL
- Nedd4-PM
- neural precursor cell expressed, developmentally down-regulated 4
- ubiquitin-protein ligase Nedd4
- E3 ubiquitin-protein ligase NEDD4-like
- e3 ubiquitin-protein ligase NEDD4-like
- neural precursor cell expressed, developmentally down-regulated gene 4A
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