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NFYA Produits

(Nuclear Transcription Factor Y, alpha (NFYA))
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008].

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Catégories NFYA en vedette

NFYA Anticorps

High quality antibodies with extensive validation data.

NFYA Kits ELISA

Reliable ELISA kits for a wide range of species.

NFYA Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

NFYA recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
N° du produit ABIN6257371
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Bat, Cow, Dog, Guinea Pig, Horse, Human, Monkey, Mouse, Pig, Rabbit, Rat
Application WB, IHC, IHC (p)
Validations
  • (3)
N° du produit ABIN6735785
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (4)
  • (1)
N° du produit ABIN104769
Quantité 100 μg
Fiche technique Fiche technique

NFYA recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative DNA-Binding ELISA
Validations
N° du produit ABIN5648500
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Semi-Quantitative DNA-Binding ELISA
Validations
N° du produit ABIN5526700
Quantité 96 tests
Fiche technique Fiche technique

NFYA recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7124216
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1312517
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1312515
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits NFYA

Jin, Yang, Li, Yang, Ma, Zhang: "p53-targeted lincRNA-p21 acts as a tumor suppressor by inhibiting JAK2/STAT3 signaling pathways in head and neck squamous cell carcinoma." dans: Molecular cancer, Vol. 18, Issue 1, pp. 38, (2019) (PubMed).

Falcone, Grandoni, Garibaldi, Manni, Filligoi, Piaggio, Gurtner: "Infinity: An In-Silico Tool for Genome-Wide Prediction of Specific DNA Matrices in miRNA Genomic Loci." dans: PLoS ONE, Vol. 11, Issue 4, pp. e0153658, (2016) (PubMed).

Morachis, Murawsky, Emerson: "Regulation of the p53 transcriptional response by structurally diverse core promoters." dans: Genes & development, Vol. 24, Issue 2, pp. 135-47, (2010) (PubMed).

Manni, Caretti, Artuso, Gurtner, Emiliozzi, Sacchi, Mantovani, Piaggio: "Posttranslational regulation of NF-YA modulates NF-Y transcriptional activity." dans: Molecular biology of the cell, Vol. 19, Issue 12, pp. 5203-13, (2008) (PubMed).

Gurtner, Fuschi, Magi, Colussi, Gaetano, Dobbelstein, Sacchi, Piaggio: "NF-Y dependent epigenetic modifications discriminate between proliferating and postmitotic tissue." dans: PLoS ONE, Vol. 3, Issue 4, pp. e2047, (2008) (PubMed).

Bennett, Seo, Datta, Shin, Osborne: "Selective binding of sterol regulatory element-binding protein isoforms and co-regulatory proteins to promoters for lipid metabolic genes in liver." dans: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15628-37, (2008) (PubMed).

Chia, Leung, Krushel, Alajez, Lo, Busson, Klamut, Bastianutto, Liu: "Nuclear factor-Y and Epstein Barr virus in nasopharyngeal cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 14, Issue 4, pp. 984-94, (2008) (PubMed).

Paradkar, Roth: "Expression of the 1B isoforms of divalent metal transporter (DMT1) is regulated by interaction of NF-Y with a CCAAT-box element near the transcription start site." dans: Journal of cellular physiology, Vol. 211, Issue 1, pp. 183-8, (2007) (PubMed).

Cecchinelli, Lavra, Rinaldo, Iacovelli, Gurtner, Gasbarri, Ulivieri, Del Prete, Trovato, Piaggio, Bartolazzi, Soddu, Sciacchitano: "Repression of the antiapoptotic molecule galectin-3 by homeodomain-interacting protein kinase 2-activated p53 is required for p53-induced apoptosis." dans: Molecular and cellular biology, Vol. 26, Issue 12, pp. 4746-57, (2006) (PubMed).

Huang, Wu, Choo: "Transcriptional modulation of the pre-implantation embryo-specific Rnf35 gene by the Y-box protein NF-Y/CBF." dans: The Biochemical journal, Vol. 387, Issue Pt 2, pp. 367-75, (2005) (PubMed).

Synonymes et noms alternatifs relatifs à NFYA

nuclear transcription factor Y, alpha (nfya), nuclear transcription factor Y subunit alpha (NFYA), nuclear transcription factor-Y alpha (Nfya), nuclear transcription factor Y subunit alpha (Nfya), AA407810, CBF-A, CBF-B, Cbf-b, HAP2, ik:tdsubc_2b6, NF-YA, NFYA, SEZ-10, SEZ10, wu:fb16e03, xx:tdsubc_2b6

Protein level used designations for NFYA

  • fb16e03
  • tdsubc_2b6
  • nuclear transcription factor Y, alpha
  • CAAT box DNA-binding protein subunit A
  • CAAT-box DNA binding protein subunit A
  • CCAAT-binding transcription factor subunit B
  • HAP2 CCAAT-binding protein
  • Transcription factor NF-Y, A subunit
  • nuclear transcription factor Y subunit A
  • nuclear transcription factor Y subunit alpha
  • CAAT-box DNA-binding protein subunit A
  • NF-Y protein chain A
  • nuclear transcription factor-Y alpha
  • NF-YA
  • CBF-B
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