NPC1L1 Produits
(NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 (NPC1L1))
Catégories
The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
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Catégories NPC1L1 en vedette
NPC1L1 Anticorps
High quality antibodies with extensive validation data.
NPC1L1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
NPC1L1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB
Validations
- (5)
- (1)
N° du produit
ABIN1881583
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IHC (p)
Validations
- (2)
N° du produit
ABIN1804672
Quantité
50 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (1)
N° du produit
ABIN7127645
Quantité
100 μL
Fiche technique
Fiche technique
NPC1L1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7491703
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN7490787
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN2854025
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits NPC1L1
: "Lipid-lowering effects of Coffea arabica pulp aqueous extract in Caco-2 cells and hypercholesterolemic rats." dans: Phytomedicine : international journal of phytotherapy and phytopharmacology, Vol. 52, pp. 187-197, (2019) (PubMed).: "The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling." dans: JCI insight, Vol. 4, Issue 3, (2019) (PubMed).
: "Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice." dans: Molecular pharmacology, Vol. 96, Issue 1, pp. 47-55, (2019) (PubMed).
: "NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains." dans: Journal of lipid research, Vol. 59, Issue 11, pp. 2181-2187, (2018) (PubMed).
: "Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease." dans: The Korean journal of internal medicine, (2018) (PubMed).
: "Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane." dans: Nutrition & metabolism, Vol. 13, pp. 48, (2016) (PubMed).
: "Intestinal CREBH overexpression prevents high-cholesterol diet-induced hypercholesterolemia by reducing Npc1l1 expression." dans: Molecular metabolism, Vol. 5, Issue 11, pp. 1092-1102, (2016) (PubMed).
: "Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism." dans: Biochimica et biophysica acta, Vol. 1861, Issue 9 Pt A, pp. 1132-41, (2016) (PubMed).
: "Hypocholesterolemic Activity of Curcumin Is Mediated by Down-regulating the Expression of Niemann-Pick C1-like 1 in Hamsters." dans: Journal of agricultural and food chemistry, Vol. 65, Issue 2, pp. 276-280, (2016) (PubMed).
: "NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy." dans: Science translational medicine, Vol. 7, Issue 275, pp. 275ra23, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à NPC1L1
NPC1 like intracellular cholesterol transporter 1 (NPC1L1), NPC1 like 1 (npc1l1), NPC1-like 1 (npc1l1), NPC1 like intracellular cholesterol transporter 1 (Npc1l1), 9130221N23Rik, Gm243, NPC1L1, NPC11L1Protein level used designations for NPC1L1
- NPC1-like 1
- NPC1 (Niemann-Pick disease, type C1, gene)-like 1
- Niemann-Pick C1-like protein 1
- Niemann-Pick C1-like 1 protein
- Niemann-Pick C1-like protein 1-like
- Niemann-Pick disease, type C1
- Niemann-Pick disease, type C1-like 1
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