NR1I2 Produits
(Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))
Catégories
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008].
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Catégories NR1I2 en vedette
NR1I2 Anticorps
High quality antibodies with extensive validation data.
NR1I2 Kits ELISA
Reliable ELISA kits for a wide range of species.
NR1I2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
NR1I2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro)
Validations
- (6)
N° du produit
ABIN738816
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p), IF
Validations
- (5)
N° du produit
ABIN652618
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (5)
N° du produit
ABIN5542364
Quantité
100 μL
Fiche technique
Fiche technique
NR1I2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6958259
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969013
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969012
Quantité
96 tests
Fiche technique
Fiche technique
NR1I2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1312940
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1787822
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7397780
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits NR1I2
: "Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis." dans: Pediatric research, Vol. 83, Issue 5, pp. 1031-1040, (2018) (PubMed).: "Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway." dans: Scientific reports, Vol. 6, pp. 27876, (2016) (PubMed).
: "Cross-talk between EPAS-1/HIF-2α and PXR signaling pathway regulates multi-drug resistance of stomach cancer cell." dans: The international journal of biochemistry & cell biology, Vol. 72, pp. 73-88, (2016) (PubMed).
: "Bortezomib and ixazomib protect firefly luciferase from degradation and can flaw respective reporter gene assays." dans: Analytical biochemistry, Vol. 509, pp. 124-9, (2016) (PubMed).
: "St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins." dans: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, Vol. 66, Issue 2, pp. 203-14, (2015) (PubMed).
: "Desmethyl bosentan displays a similar in vitro interaction profile as bosentan." dans: Pulmonary pharmacology & therapeutics, Vol. 30, pp. 80-6, (2015) (PubMed).
: "3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease." dans: Pharmacological research, Vol. 100, pp. 64-72, (2015) (PubMed).
: "Obatoclax as a perpetrator in drug-drug interactions and its efficacy in multidrug resistance cell lines." dans: The Journal of pharmacy and pharmacology, Vol. 67, Issue 11, pp. 1575-84, (2015) (PubMed).
: "Involvement of pregnane xenobiotic receptor in mating-induced allopregnanolone formation in the midbrain and hippocampus and brain-derived neurotrophic factor in the hippocampus among female rats." dans: Psychopharmacology, Vol. 231, Issue 17, pp. 3375-90, (2014) (PubMed).
: "Pharmacokinetic interaction profile of riociguat, a new soluble guanylate cyclase stimulator, in vitro." dans: Pulmonary pharmacology & therapeutics, Vol. 28, Issue 2, pp. 130-7, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à NR1I2
nuclear receptor subfamily 1 group I member 2 (NR1I2), nuclear receptor subfamily 1, group I, member 2 (Nr1i2), nuclear receptor subfamily 1 group I member 2 (Nr1i2), nuclear receptor subfamily 1 group I member 2 S homeolog (nr1i2.S), nuclear receptor subfamily 1, group I, member 2 (nr1i2), BXR, bxr, mPXR, nr1i2, ONR1, onr1, PAR, PAR1, PAR2, PARq, PRR, PXR, PXR.1, PXR.2, PXR1, SAR, SXR, xonr1Protein level used designations for NR1I2
- nuclear receptor subfamily 1 group I member 2
- orphan nuclear receptor PAR1
- orphan nuclear receptor PXR
- pregnane X nuclear receptor variant 2
- pregnane X receptor
- steroid and xenobiotic receptor
- Pregnane X receptor
- nuclear receptor subfamily 1, group 1, member 2
- pregnane X receptor (nuclear receptor sub family 1, group I, member 2)
- nuclear receptor subfamily 1 group I member 2 S homeolog
- nuclear receptor subfamily 1, group I, member 2
- orphan nuclear receptor BXR-beta
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