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NUAK1 Produits

(NUAK Family, SNF1-Like Kinase, 1 (NUAK1))

Catégories

Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.

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Catégories NUAK1 en vedette

NUAK1 Anticorps

High quality antibodies with extensive validation data.

NUAK1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

NUAK1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Hamster, Human, Mouse
Application WB, IHC (p)
Validations
  • (1)
  • (2)
N° du produit ABIN392639
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, IHC (p)
Validations
  • (1)
  • (2)
N° du produit ABIN392640
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
N° du produit ABIN716396
Quantité 100 μL
Fiche technique Fiche technique

NUAK1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6227500
Quantité 96 tests
Fiche technique Fiche technique

NUAK1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1313130
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1313129
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Insect Cells
Validations
N° du produit ABIN5509049
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits NUAK1

Humbert, Navaratnam, Augert, Da Costa, Martien, Wang, Martinez, Abbadie, Carling, de Launoit, Gil, Bernard: "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." dans: The EMBO journal, Vol. 29, Issue 2, pp. 376-86, (2010) (PubMed).

Niesler, Myburgh, Moore: "The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis." dans: Experimental physiology, Vol. 92, Issue 1, pp. 207-17, (2007) (PubMed).

Suzuki, Lu, Kusakai, Kishimoto, Ogura, Esumi: "ARK5 is a tumor invasion-associated factor downstream of Akt signaling." dans: Molecular and cellular biology, Vol. 24, Issue 8, pp. 3526-35, (2004) (PubMed).

Kusakai, Suzuki, Ogura, Kaminishi, Esumi: "Strong association of ARK5 with tumor invasion and metastasis." dans: Journal of experimental & clinical cancer research : CR, Vol. 23, Issue 2, pp. 263-8, (2004) (PubMed).

Suzuki, Kusakai, Kishimoto, Lu, Ogura, Esumi: "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation." dans: Oncogene, Vol. 22, Issue 40, pp. 6177-82, (2003) (PubMed).

Suzuki, Kusakai, Kishimoto, Lu, Ogura, Lavin, Esumi: "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein." dans: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 48-53, (2002) (PubMed).

Synonymes et noms alternatifs relatifs à NUAK1

NUAK family kinase 1 (NUAK1), NUAK family, SNF1-like kinase, 1 (Nuak1), ARK5, AU014801, AW494241, B230104P22Rik, Omphk1

Protein level used designations for NUAK1

  • AMP-activated protein kinase family member 5
  • AMPK-related protein kinase 5
  • NUAK family SNF1-like kinase 1
  • omphalocele kinase 1
  • ZNUAK family, SNF1-like kinase, 1
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