NUAK1 Produits
(NUAK Family, SNF1-Like Kinase, 1 (NUAK1))
Catégories
Serine/threonine-protein kinase involved in various processes such as cell adhesion, regulation of cell ploidy and senescence, cell proliferation and tumor progression. Phosphorylates ATM, CASP6, LATS1, PPP1R12A and p53/TP53. Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of 'Ser-464' of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex. Acts by mediating PPP1R12A then interacts with 14-3-3, leading to reduced dephosphorylation of myosin MLC2 by myosin PP1. May be involved in 392' and is recruited to the CDKN1A/WAF1 promoter to participate to transcription activation by p53/TP53. May also act as a tumor malignancy-associated factor by promoting tumor invasion and metastasis under regulation and phosphorylation by AKT1. Suppresses Fas-induced apoptosis by mediating phosphorylation of CASP6, thereby suppressing the activation of the caspase and the subsequent cleavage of CFLAR.
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Catégories NUAK1 en vedette
NUAK1 Anticorps
High quality antibodies with extensive validation data.
NUAK1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
NUAK1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Hamster, Human, Mouse
Application
WB, IHC (p)
Validations
- (1)
- (2)
N° du produit
ABIN392639
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, IHC (p)
Validations
- (1)
- (2)
N° du produit
ABIN392640
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
N° du produit
ABIN716396
Quantité
100 μL
Fiche technique
Fiche technique
NUAK1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6227500
Quantité
96 tests
Fiche technique
Fiche technique
NUAK1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1313130
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1313129
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5509049
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits NUAK1
: "Regulation of ploidy and senescence by the AMPK-related kinase NUAK1." dans: The EMBO journal, Vol. 29, Issue 2, pp. 376-86, (2010) (PubMed).: "The changing AMPK expression profile in differentiating mouse skeletal muscle myoblast cells helps confer increasing resistance to apoptosis." dans: Experimental physiology, Vol. 92, Issue 1, pp. 207-17, (2007) (PubMed).
: "ARK5 is a tumor invasion-associated factor downstream of Akt signaling." dans: Molecular and cellular biology, Vol. 24, Issue 8, pp. 3526-35, (2004) (PubMed).
: "Strong association of ARK5 with tumor invasion and metastasis." dans: Journal of experimental & clinical cancer research : CR, Vol. 23, Issue 2, pp. 263-8, (2004) (PubMed).
: "ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation." dans: Oncogene, Vol. 22, Issue 40, pp. 6177-82, (2003) (PubMed).
: "Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein." dans: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 48-53, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à NUAK1
NUAK family kinase 1 (NUAK1), NUAK family, SNF1-like kinase, 1 (Nuak1), ARK5, AU014801, AW494241, B230104P22Rik, Omphk1Protein level used designations for NUAK1
- AMP-activated protein kinase family member 5
- AMPK-related protein kinase 5
- NUAK family SNF1-like kinase 1
- omphalocele kinase 1
- ZNUAK family, SNF1-like kinase, 1
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- Nucleaoside Diphosphate Kinase
- Nuclear Antigen
- Nuclear Casein Kinase and Cyclin-Dependent Kinase Substrate 1
- Nuclear Factor 1
- Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, alpha
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- Nuclear Marker
- Nuclear Matrix Protein 22
- Nuclear Receptor Subfamily 1, Group D, Member 2
- Nuclear Receptor Subfamily 1, Group H, Member 2/3
- Nuclear Receptor Subfamily 2, Group C, Member 1
- Nuclear Transcription Factor Y, beta
- Nuclease
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