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NUDT1 Produits

(Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1 (NUDT1))

Catégories

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008].

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Catégories NUDT1 en vedette

NUDT1 Anticorps

High quality antibodies with extensive validation data.

NUDT1 Kits ELISA

Reliable ELISA kits for a wide range of species.

NUDT1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

NUDT1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application IHC, ELISA, IF
Validations
  • (3)
N° du produit ABIN7142858
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IP
Validations
  • (3)
N° du produit ABIN518070
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (3)
N° du produit ABIN561864
Quantité 100 μg
Fiche technique Fiche technique

NUDT1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969035
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6730563
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6226065
Quantité 96 tests
Fiche technique Fiche technique

NUDT1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1313165
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7124237
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN2130907
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits NUDT1

Hashiguchi, Hayashi, Sekiguchi, Umezu: "The roles of human MTH1, MTH2 and MTH3 proteins in maintaining genome stability under oxidative stress." dans: Mutation research, Vol. 808, pp. 10-19, (2019) (PubMed).

Pompsch, Vogel, Classen, Kranz, Iliakis, Riffkin, Brockmeier, Metzen: "The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia." dans: BMC cancer, Vol. 18, Issue 1, pp. 1190, (2019) (PubMed).

Zhou, Ma, Yang, Qiao, Li, Guo, Ma, Zhao, Wang, Jiang, Wan, Adam Goscinski, Ding, Zheng, Li, Liu, Suo, Zhao: "Potent and specific MTH1 inhibitors targeting gastric cancer." dans: Cell death & disease, Vol. 10, Issue 6, pp. 434, (2019) (PubMed).

McPherson, Troccoli, Ji, Bowles, Gardiner, Mohsen, Nagathihalli, Nguyen, Robbins, Merchant, Kool, Rai, Ford: "Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue." dans: DNA repair, pp. 102644, (2019) (PubMed).

Page, Valerie, Wright, Wallner, Isaksson, Carter, Rudd, Loseva, Jemth, Almlöf, Font-Mateu, Llona-Minguez, Baranczewski, Jeppsson, Homan, Almqvist, Axelsson, Regmi, Gustavsson, Lundbäck, Scobie et al.: "Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells. ..." dans: Nature communications, Vol. 9, Issue 1, pp. 250, (2018) (PubMed).

Fan, Zhao, Parro, Zhao, Chou, Robert, Deeb, Raynoschek, Barichievy, Engkvist, Maresca, Hicks, Meuller, Moss, Brandon, Wood, Kulic, Wellington: "Small molecule inducers of ABCA1 and apoE that act through indirect activation of the LXR pathway." dans: Journal of lipid research, Vol. 59, Issue 5, pp. 830-842, (2018) (PubMed).

Zou, Owusu, Harris, Jackson, Loizou, Nik-Zainal: "Validating the concept of mutational signatures with isogenic cell models." dans: Nature communications, Vol. 9, Issue 1, pp. 1744, (2018) (PubMed).

Eshtad, Mavajian, Rudd, Visnes, Boström, Altun, Helleday: "hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia." dans: Oncogenesis, Vol. 5, Issue 12, pp. e275, (2016) (PubMed).

Zhou, Jian, Leng, Liu, Tian, Wang, Gao, Yang, Chen: "Human MutT homologue 1 mRNA overexpression correlates to poor response of multiple myeloma." dans: International journal of hematology, Vol. 105, Issue 3, pp. 318-325, (2016) (PubMed).

Patel, Burton, Halvorsen, Balkan, Reiner, Perez-Stable, Cohen, Munoz, Giribaldi, Singh, Robbins, Nguyen, Rai: "MutT Homolog 1 (MTH1) maintains multiple KRAS-driven pro-malignant pathways." dans: Oncogene, Vol. 34, Issue 20, pp. 2586-96, (2015) (PubMed).

Synonymes et noms alternatifs relatifs à NUDT1

7,8-dihydro-8-oxoguanine triphosphatase (mth1), 7,8-dihydro-8-oxoguanine triphosphatase (Tsp_07498), nudix hydrolase 1 (nudt1), 7,8-dihydro-8-oxoguanine triphosphatase (8odp), nudix hydrolase 1 (NUDT1), nudix (nucleoside diphosphate linked moiety X)-type motif 1 (Nudt1), nudix hydrolase 1 (Nudt1), MTH1, Mth1, mutT, nudT1

Protein level used designations for NUDT1

  • 7,8-dihydro-8-oxoguanine triphosphatase
  • 2-hydroxy-dATP diphosphatase
  • 8-oxo-7,8-dihydrodeoxyguanosine triphosphatase
  • 8-oxo-7,8-dihydroguanosine triphosphatase
  • 8-oxo-dGTPase
  • mutT human homolog 1
  • nucleoside diphosphate-linked moiety X motif 1
  • nucleoside diphosphate-linked moiety X-type motif 1
  • nudix motif 1
  • 8-oxo-7,8-dihydro-2'-dGTPase
  • mutT human homolog (8-oxo-dGTPase)
  • nudix-type motif 1
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