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PABPC4 Produits

(Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) (PABPC4))

Catégories

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].

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Catégories PABPC4 en vedette

PABPC4 Anticorps

High quality antibodies with extensive validation data.

PABPC4 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (4)
N° du produit ABIN6145149
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC, ELISA, IP
Validations
  • (2)
N° du produit ABIN6264006
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Bat, Dog, Horse, Human, Monkey, Mouse, Rat
Application WB, IHC, IHC (p)
Validations
  • (2)
N° du produit ABIN202848
Quantité 100 μL
Fiche technique Fiche technique

PABPC4 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6229821
Quantité 96 tests
Fiche technique Fiche technique

PABPC4 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3085250
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits PABPC4

Kuppers, Arora, Lim, Lim, Carter, Corrin, Plaisier, Basom, Delrow, Wang, Hansen He, Torok-Storb, Hsieh, Paddison: "N6-methyladenosine mRNA marking promotes selective translation of regulons required for human erythropoiesis." dans: Nature communications, Vol. 10, Issue 1, pp. 4596, (2019) (PubMed).

Hsu, Hsu, Hsueh, Wang, Wu, Wu, Liu, Yu, Chang, Yu: "Identification and Characterization of Potential Biomarkers by Quantitative Tissue Proteomics of Primary Lung Adenocarcinoma." dans: Molecular & cellular proteomics : MCP, Vol. 15, Issue 7, pp. 2396-410, (2016) (PubMed).

Kini, Kong, Liebhaber: "Cytoplasmic poly(A) binding protein C4 serves a critical role in erythroid differentiation." dans: Molecular and cellular biology, Vol. 34, Issue 7, pp. 1300-9, (2014) (PubMed).

Datu, Bag: "Enhanced translation of mRNAs encoding proteins involved in mRNA translation during recovery from heat shock." dans: PLoS ONE, Vol. 8, Issue 5, pp. e64171, (2013) (PubMed).

Bhattacharjee, Bag: "Depletion of nuclear poly(A) binding protein PABPN1 produces a compensatory response by cytoplasmic PABP4 and PABP5 in cultured human cells." dans: PLoS ONE, Vol. 7, Issue 12, pp. e53036, (2013) (PubMed).

Liu, Yin, Wang, Ju, Chen, Qiu, Li, Peng, Lu: "Cytoplasmic poly(A) binding protein 4 is highly expressed in human colorectal cancer and correlates with better prognosis." dans: Journal of genetics and genomics = Yi chuan xue bao, Vol. 39, Issue 8, pp. 369-74, (2012) (PubMed).

Okada-Katsuhata, Yamashita, Kutsuzawa, Izumi, Hirahara, Ohno: "N- and C-terminal Upf1 phosphorylations create binding platforms for SMG-6 and SMG-5:SMG-7 during NMD." dans: Nucleic acids research, Vol. 40, Issue 3, pp. 1251-66, (2012) (PubMed).

Katzenellenbogen, Vliet-Gregg, Xu, Galloway: "Cytoplasmic poly(A) binding proteins regulate telomerase activity and cell growth in human papillomavirus type 16 E6-expressing keratinocytes." dans: Journal of virology, Vol. 84, Issue 24, pp. 12934-44, (2010) (PubMed).

Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: "Large-scale mapping of human protein-protein interactions by mass spectrometry. ..." dans: Molecular systems biology, Vol. 3, pp. 89, (2007) (PubMed).

Synonymes et noms alternatifs relatifs à PABPC4

polyadenylate-binding protein 4 (Bm1_06880), poly(A) binding protein, cytoplasmic 4 (Pabpc4), poly(A) binding protein, cytoplasmic 4 (inducible form) (pabpc4), poly(A) binding protein cytoplasmic 4 L homeolog (pabpc4.L), poly(A) binding protein cytoplasmic 4 (PABPC4), APP-1, APP1, cb12, ePAB, ePABP, iPABP, PABP, PABP4, sb:cb12

Protein level used designations for PABPC4

  • polyadenylate-binding protein 4
  • poly(A) binding protein, cytoplasmic 4 (inducible form)
  • PABP-4
  • activated-platelet protein 1
  • inducible poly(A)-binding protein
  • poly(A)-binding protein 4
  • poly A binding protein, cytoplasmic 4
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