PAK6 Produits
(P21-Activated Kinase 6 (PAK6))
Catégories
This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved in transcriptional regulation. Changes in expression of this gene have been linked to prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013].
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Catégories PAK6 en vedette
PAK6 Anticorps
High quality antibodies with extensive validation data.
PAK6 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PAK6 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC (p), IF
Validations
- (4)
N° du produit
ABIN656098
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (5)
N° du produit
ABIN3032120
Quantité
0.4 mL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (3)
N° du produit
ABIN528014
Quantité
100 μg
Fiche technique
Fiche technique
PAK6 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6218404
Quantité
96 tests
Fiche technique
Fiche technique
PAK6 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1313930
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7505270
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
N° du produit
ABIN5509060
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PAK6
: "Pyruvate kinase M2 promotes pancreatic ductal adenocarcinoma invasion and metastasis through phosphorylation and stabilization of PAK2 protein." dans: Oncogene, Vol. 37, Issue 13, pp. 1730-1742, (2019) (PubMed).: "Chronic exposure to cigarette smoke leads to activation of p21 (RAC1)-activated kinase 6 (PAK6) in non-small cell lung cancer cells." dans: Oncotarget, Vol. 7, Issue 38, pp. 61229-61245, (2016) (PubMed).
: "P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretion." dans: The Journal of biological chemistry, Vol. 288, Issue 5, pp. 3025-35, (2013) (PubMed).
: "Diversity of antigen-specific responses induced in vivo with CTLA-4 blockade in prostate cancer patients." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 189, Issue 7, pp. 3759-66, (2012) (PubMed).
: "Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase." dans: The Journal of biological chemistry, Vol. 280, Issue 5, pp. 3323-30, (2005) (PubMed).
: "Mechanism of p21-activated kinase 6-mediated inhibition of androgen receptor signaling." dans: The Journal of biological chemistry, Vol. 279, Issue 3, pp. 1922-31, (2004) (PubMed).
: "Identification of an autoinhibitory domain of p21-activated protein kinase 5." dans: The Journal of biological chemistry, Vol. 278, Issue 36, pp. 33621-4, (2003) (PubMed).
: "p21-activated kinases: three more join the Pak." dans: The international journal of biochemistry & cell biology, Vol. 34, Issue 7, pp. 713-7, (2002) (PubMed).
: "AR and ER interaction with a p21-activated kinase (PAK6)." dans: Molecular endocrinology (Baltimore, Md.), Vol. 16, Issue 1, pp. 85-99, (2002) (PubMed).
: "Cloning and characterization of PAK5, a novel member of mammalian p21-activated kinase-II subfamily that is predominantly expressed in brain." dans: Oncogene, Vol. 21, Issue 24, pp. 3939-48, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à PAK6
p21 (RAC1) activated kinase 6 (PAK6), p21 protein (Cdc42/Rac)-activated kinase 6 (Pak6), p21 (RAC1) activated kinase 6 (Pak6), p21 protein (Cdc42/Rac)-activated kinase 6b (pak6b), p21 protein (Cdc42/Rac)-activated kinase 6 (PAK6), 4732456M09, PAK5, pak6, si:ch211-158b22.3Protein level used designations for PAK6
- p21(CDKN1A)-activated kinase 6
- serine/threonine-protein kinase PAK 6
- PAK-6
- p21-activated kinase 6
- p21 (CDKN1A)-activated kinase 6
- p21 protein (Cdc42/Rac)-activated kinase 6
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