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PANK2 Produits

(Pantothenate Kinase 2 (PANK2))

Catégories

This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008].

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Catégories PANK2 en vedette

PANK2 Anticorps

High quality antibodies with extensive validation data.

PANK2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PANK2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Dog, Human, Monkey, Rat
Application WB, IHC, IF, IHC (p), FACS
Validations
  • (8)
N° du produit ABIN1500026
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (3)
N° du produit ABIN7162603
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (3)
N° du produit ABIN566414
Quantité 100 μg
Fiche technique Fiche technique

PANK2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6206931
Quantité 96 tests
Fiche technique Fiche technique

PANK2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN3013381
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7421605
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7421602
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PANK2

Santambrogio, Dusi, Guaraldo, Rotundo, Broccoli, Garavaglia, Tiranti, Levi: "Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients." dans: Neurobiology of disease, (2015) (PubMed).

Huang, Chu, Jiang, Chen, Zhang, Zeng: "Glycyrrhizin suppresses lung adenocarcinoma cell growth through inhibition of thromboxane synthase." dans: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 33, Issue 2, pp. 375-88, (2014) (PubMed).

Zeman, Lin, Freire, Cimprich: "DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis." dans: The Journal of cell biology, Vol. 206, Issue 2, pp. 183-97, (2014) (PubMed).

Barrett, Fang, Gargano, Markovich, Kocarek, Runge-Morris: "Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency." dans: Drug metabolism and disposition: the biological fate of chemicals, Vol. 41, Issue 8, pp. 1505-13, (2013) (PubMed).

Brunetti, Dusi, Morbin, Uggetti, Moda, DAmato, Giordano, dAmati, Cozzi, Levi, Hayflick, Tiranti: "Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model." dans: Human molecular genetics, Vol. 21, Issue 24, pp. 5294-305, (2012) (PubMed).

Hörtnagel, Prokisch, Meitinger: "An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria." dans: Human molecular genetics, Vol. 12, Issue 3, pp. 321-7, (2003) (PubMed).

Houlden, Lincoln, Farrer, Cleland, Hardy, Orrell: "Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic." dans: Neurology, Vol. 61, Issue 10, pp. 1423-6, (2003) (PubMed).

Ching, Westaway, Gitschier, Higgins, Hayflick: "HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration." dans: Neurology, Vol. 58, Issue 11, pp. 1673-4, (2002) (PubMed).

Synonymes et noms alternatifs relatifs à PANK2

pantothenate kinase 2 (PANK2), pantothenate kinase 2 (Tsp_01576), pantothenate kinase 2, mitochondrial (LOC100539295), pantothenate kinase 2 (Pank2), ribonuclease A family member 11 (inactive) (RNASE11), 4933409I19Rik, AI642621, ATPANK2, C20orf48, F10M6.180, F10M6_180, HARP, HSS, NBIA1, PANK2, pantothenate kinase 2, PKAN

Protein level used designations for PANK2

  • pantothenate kinase 2 (Hallervorden-Spatz syndrome)
  • pantothenate kinase 2
  • pantothenate kinase 2, mitochondrial-like
  • Hallervorden-Spatz syndrome
  • pantothenate kinase 2, mitochondrial
  • pantothenic acid kinase 2
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