PAX5 Produits
(Paired Box 5 (PAX5))
Catégories
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9\;14)(p13\;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
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Catégories PAX5 en vedette
PAX5 Anticorps
High quality antibodies with extensive validation data.
PAX5 Kits ELISA
Reliable ELISA kits for a wide range of species.
PAX5 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PAX5 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), RNAi
Validations
- (6)
N° du produit
ABIN562112
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
- (4)
N° du produit
ABIN1098104
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
IHC, StM
Validations
- (5)
N° du produit
ABIN6940256
Quantité
100 μg
Fiche technique
Fiche technique
PAX5 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1381403
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN5661953
Quantité
96 tests
Fiche technique
Fiche technique
PAX5 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124296
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1314073
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1314071
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PAX5
: "Hemophagocytic lymphohistiocytosis presenting with annular erythema multiforme-like eruptions in a patient with angioimmunoblastic T cell lymphoma: A case report." dans: Experimental and therapeutic medicine, Vol. 16, Issue 3, pp. 2060-2065, (2018) (PubMed).: "PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene." dans: Gene, Vol. 555, Issue 2, pp. 194-202, (2014) (PubMed).
: "The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease." dans: Cancer research, Vol. 71, Issue 24, pp. 7345-50, (2011) (PubMed).
: "The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance." dans: The Journal of experimental medicine, Vol. 208, Issue 3, pp. 455-67, (2011) (PubMed).
: "Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. ..." dans: Blood, Vol. 115, Issue 15, pp. 3089-97, (2010) (PubMed).
: "Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker." dans: American journal of clinical pathology, Vol. 133, Issue 1, pp. 41-8, (2009) (PubMed).
: "Multiple isoforms of PAX5 are expressed in both lymphomas and normal B-cells." dans: British journal of haematology, Vol. 147, Issue 3, pp. 328-38, (2009) (PubMed).
: "Transcriptional analysis of the B cell germinal center reaction." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2639-44, (2003) (PubMed).
: "Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma." dans: Oncogene, Vol. 21, Issue 32, pp. 4908-20, (2002) (PubMed).
: "Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin." dans: Blood, Vol. 94, Issue 9, pp. 3108-13, (1999) (PubMed).
Synonymes et noms alternatifs relatifs à PAX5
paired box 5 (PAX5), paired box 5 L homeolog (pax5.L), paired box 5 (Pax5), paired box 5 (pax5), BSAP, EBB-1, KLP, noi, Pax-5, pax2.1, pax2a, PAX5, pax5-a, paxzf-b, Pax[Zf-b], RGD1565236Protein level used designations for PAX5
- paired box 5
- paired box gene 5 (B-cell lineage specific activator)
- paired box protein Pax-5
- paired box protein Pax-5-like
- B-cell lineage specific activator
- paired box homeotic gene 5
- paired domain gene 5
- transcription factor PAX 5
- XPax-5
- B-cell-specific transcription factor
- Pax5 variant 1
- Pax5 variant 2
- No isthmus protein
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