p130 Produits
(Retinoblastoma-Like 2 (p130) (RBL2))
Catégories
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.
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Catégories p130 en vedette
p130 Anticorps
High quality antibodies with extensive validation data.
p130 Kits ELISA
Reliable ELISA kits for a wide range of species.
p130 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
p130 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, FACS
Validations
- (1)
- (3)
N° du produit
ABIN656158
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, WB, FACS
Validations
- (4)
N° du produit
ABIN5542553
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Blow Fly, Chicken, Human, Mouse, Rat
Application
WB, IF, IHC, IP
Validations
- (5)
- (3)
N° du produit
ABIN967864
Quantité
150 μg
Fiche technique
Fiche technique
p130 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1155325
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1155326
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1155327
Quantité
96 tests
Fiche technique
Fiche technique
p130 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1317571
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2730602
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits p130
: "Sj7170, a unique dual-function peptide with a specific ?-chymotrypsin inhibitory activity and a potent tumor-activating effect from scorpion venom." dans: The Journal of biological chemistry, Vol. 289, Issue 17, pp. 11667-80, (2014) (PubMed).: "Peroxisome proliferator-activated receptor β/δ cross talks with E2F and attenuates mitosis in HRAS-expressing cells." dans: Molecular and cellular biology, Vol. 32, Issue 11, pp. 2065-82, (2012) (PubMed).
: "A small molecule based on the pRb2/p130 spacer domain leads to inhibition of cdk2 activity, cell cycle arrest and tumor growth reduction in vivo." dans: Oncogene, Vol. 26, Issue 13, pp. 1829-39, (2007) (PubMed).
: "From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway." dans: Journal of cellular biochemistry, Vol. 102, Issue 6, pp. 1400-4, (2007) (PubMed).
: "Frequent loss of pRb2/p130 in human ovarian carcinoma." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 9, pp. 3098-103, (2004) (PubMed).
: "Differential regulation of Rb family proteins and prohibitin during camptothecin-induced apoptosis." dans: Oncogene, Vol. 21, Issue 29, pp. 4539-48, (2002) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "FGF signaling targets the pRb-related p107 and p130 proteins to induce chondrocyte growth arrest." dans: The Journal of cell biology, Vol. 158, Issue 4, pp. 741-50, (2002) (PubMed).
: "The retinoblastoma family: twins or distant cousins?" dans: Genome biology, Vol. 3, Issue 9, pp. reviews3012, (2002) (PubMed).
: "p107 and p130: versatile proteins with interesting pockets." dans: Experimental cell research, Vol. 264, Issue 1, pp. 135-47, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à p130
retinoblastoma-like 2 (p130) (RBL2), RB transcriptional corepressor like 2 (RBL2), related to retinoblastoma 2 (LOC541652), RB transcriptional corepressor like 2 (Rbl2), p130, P130, PRB2, Rb2, RBL2, RBR-2, RBR2, RRB2aProtein level used designations for p130
- retinoblastoma-like 2 (p130)
- retinoblastoma-like protein 2
- retinoblastoma-like protein 2-like
- CL1187_-3
- CL1187_-3(342)
- CL1187_-3_ov
- PZA00193
- RB
- RRB2b
- Retinoblastoma-related protein 2
- nPZA00193.2
- retinoblastoma-related protein 2a
- 130 kDa retinoblastoma-associated protein
- retinoblastoma-related protein 2
- P130
- PPAR-alpha-interacting complex protein 128
- PRB2
- PRIC128
- RBR-2
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