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PC Produits

(Pyruvate Carboxylase (PC))
This gene encodes pyruvate carboxylase, which requires biotin and ATP to catalyse the carboxylation of pyruvate to oxaloacetate. The active enzyme is a homotetramer arranged in a tetrahedron which is located exclusively in the mitochondrial matrix. Pyruvate carboxylase is involved in gluconeogenesis, lipogenesis, insulin secretion and synthesis of the neurotransmitter glutamate. Mutations in this gene have been associated with pyruvate carboxylase deficiency. Alternatively spliced transcript variants with different 5' UTRs, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].

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Catégories PC en vedette

PC Anticorps

High quality antibodies with extensive validation data.

PC Kits ELISA

Reliable ELISA kits for a wide range of species.

PC Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PC recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (6)
N° du produit ABIN7441475
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, ELISA, IHC
Validations
  • (3)
N° du produit ABIN238663
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IHC (p)
Validations
  • (2)
N° du produit ABIN2890557
Quantité 100 μL
Fiche technique Fiche technique

PC recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969792
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6959001
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6959002
Quantité 96 tests
Fiche technique Fiche technique

PC recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7399316
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7409011
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN2730237
Quantité 20 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PC

Caldwell, Petzinger, Jakowec, Cadenas: "Treadmill exercise rescues mitochondrial function and motor behavior in the CAG140 knock-in mouse model of Huntington's disease." dans: Chemico-biological interactions, Vol. 315, pp. 108907, (2020) (PubMed).

Rattanapornsompong, Ngamkham, Chavalit, Jitrapakdee: "Generation of Human Pyruvate Carboxylase Knockout Cell Lines Using Retrovirus Expressing Short Hairpin RNA and CRISPR-Cas9 as Models to Study Its Metabolic Role in Cancer Research." dans: Methods in molecular biology (Clifton, N.J.), Vol. 1916, pp. 273-288, (2019) (PubMed).

Toledo, Batista-Gonzalez, Merheb, Aoun, Tarabra, Feng, Sarparanta, Merlo, Botrè, Schwartz, Pessin, Singh: "Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1." dans: Cell metabolism, Vol. 28, Issue 2, pp. 268-281.e4, (2018) (PubMed).

Cardaci, Zheng, MacKay, van den Broek, MacKenzie, Nixon, Stevenson, Tumanov, Bulusu, Kamphorst, Vazquez, Fleming, Schiavi, Kalna, Blyth, Strathdee, Gottlieb: "Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis." dans: Nature cell biology, Vol. 17, Issue 10, pp. 1317-26, (2015) (PubMed).

Seale, Gilman, Hashimoto, Ogawa-Wong, Berry: "Diet-induced obesity in the selenocysteine lyase knockout mouse." dans: Antioxidants & redox signaling, Vol. 23, Issue 10, pp. 761-74, (2015) (PubMed).

Lee, Jung, Choi, Lee, Lee, Han, Kim, Kim, Lee, Kang: "Toxicity generated through inhibition of pyruvate carboxylase and carnitine palmitoyl transferase-1 is similar to high glucose/palmitate-induced glucolipotoxicity in INS-1 beta cells." dans: Molecular and cellular endocrinology, Vol. 383, Issue 1-2, pp. 48-59, (2014) (PubMed).

Tao, Zhang, Zeng, Shulman, Jin: "Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice." dans: Nature medicine, Vol. 20, Issue 11, pp. 1263-9, (2014) (PubMed).

Lee, Reyes, Gottipati, Lewis, Lesort, Parpura, Gray: "Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model." dans: Neurobiology of disease, Vol. 58, pp. 192-9, (2013) (PubMed).

Vastag, Koyuncu, Grady, Shenk, Rabinowitz: "Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism." dans: PLoS pathogens, Vol. 7, Issue 7, pp. e1002124, (2011) (PubMed).

St Maurice, Reinhardt, Surinya, Attwood, Wallace, Cleland, Rayment: "Domain architecture of pyruvate carboxylase, a biotin-dependent multifunctional enzyme." dans: Science (New York, N.Y.), Vol. 317, Issue 5841, pp. 1076-9, (2007) (PubMed).

Synonymes et noms alternatifs relatifs à PC

Pyruvate carboxylase (PCB), pyruvate carboxylase b (pcxb), PYruvate Carboxylase (pyc-1), pyruvate carboxylase (PC), pyruvate carboxylase (pyc), pyruvate carboxylase Pyr1 (pyr1), pyruvate carboxylase (CNF00650), Pyruvate carboxylase (PYC1), pyruvate carboxylase (Ndas_1152), pyruvate carboxylase (Ilyop_2503), pyruvate carboxylase (Calni_0495), pyruvate carboxylase (Ftrac_1004), pyruvate carboxylase (Plabr_3574), pyruvate carboxylase (Sgly_2936), pyruvate carboxylase (Celly_0558), pyruvate carboxylase (Hipma_0131), pyruvate carboxylase (Halhy_1567), pyruvate carboxylase (Mesop_1269), pyruvate carboxylase (Pcx), pyruvate carboxylase (Pc), BA4157, BcDNA, BcDNA:GH06348, Dmel\\CG1516, PC, Pc, Pcb, PCB, PCX, Pcx, pyc, wu:fb82g08, wu:fj85g01

Protein level used designations for PC

  • CG1516-PA
  • CG1516-PB
  • CG1516-PD
  • CG1516-PE
  • CG1516-PG
  • CG1516-PI
  • CG1516-PJ
  • CG1516-PK
  • CG1516-PL
  • CG1516-PM
  • CG1516-PP
  • GH06348
  • pyruvate carboxykinase
  • pyruvate carboxylase
  • PYCb
  • pyruvate carboxylase, mitochondrial
  • PYruvate Carboxylase family member (pyc-1)
  • Pyruvate carboxylase
  • pyruvate decarboxylase
  • pyruvic carboxylase
  • PCB
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