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PCSK1 Produits

(Proprotein Convertase Subtilisin/kexin Type 1 (PCSK1))
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a type I proinsulin-processing enzyme that plays a key role in regulating insulin biosynthesis. It is also known to cleave proopiomelanocortin, prorenin, proenkephalin, prodynorphin, prosomatostatin and progastrin. Mutations in this gene are thought to cause obesity. This encoded protein is associated with carcinoid tumors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010].

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Catégories PCSK1 en vedette

PCSK1 Anticorps

High quality antibodies with extensive validation data.

PCSK1 Kits ELISA

Reliable ELISA kits for a wide range of species.

PCSK1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PCSK1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p), ICC, IHC (fro)
Validations
  • (7)
N° du produit ABIN7435748
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Mouse
Application WB, IHC, IP, ICC
Validations
  • (6)
N° du produit ABIN7443446
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p), IF
Validations
  • (8)
N° du produit ABIN562137
Quantité 100 μg
Fiche technique Fiche technique

PCSK1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958849
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6958850
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN1571753
Quantité 96 tests
Fiche technique Fiche technique

PCSK1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1314348
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Rat
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7406851
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
N° du produit ABIN1989721
Quantité 25 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PCSK1

Evans, Rodriguez, Ragolia: "ACTH promotes chondrogenic nodule formation and induces transient elevations in intracellular calcium in rat bone marrow cell cultures via MC2-R signaling." dans: Cell and tissue research, Vol. 352, Issue 2, pp. 413-25, (2013) (PubMed).

Evans, Fernando, Ragolia: "Functional melanocortin-2 receptors are expressed by mouse aorta-derived mesenchymal progenitor cells." dans: Molecular and cellular endocrinology, Vol. 355, Issue 1, pp. 60-70, (2012) (PubMed).

Mbikay, Sirois, Nkongolo, Basak, Chrétien: "Effects of rs6234/rs6235 and rs6232/rs6234/rs6235 PCSK1 single-nucleotide polymorphism clusters on proprotein convertase 1/3 biosynthesis and activity." dans: Molecular genetics and metabolism, Vol. 104, Issue 4, pp. 682-7, (2011) (PubMed).

Jackson, Creemers, Farooqi, Raffin-Sanson, Varro, Dockray, Holst, Brubaker, Corvol, Polonsky, Ostrega, Becker, Bertagna, Hutton, White, Dattani, Hussain, Middleton, Nicole, Milla, Lindley, ORahilly: "Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency." dans: The Journal of clinical investigation, Vol. 112, Issue 10, pp. 1550-60, (2003) (PubMed).

Synonymes et noms alternatifs relatifs à PCSK1

proprotein convertase subtilisin/kexin type 1 (PCSK1), proprotein convertase subtilisin/kexin type 1 (Pcsk1), proprotein convertase subtilisin/kexin type 1 (pcsk1), prohormone convertase 1 (PC1B), BDP, BMIQ12, Nec-1, NEC1, Nec1, PC1, PC1/3, PC3, Phpp-1, SPC3

Protein level used designations for PCSK1

  • NEC 1
  • neuroendocrine convertase 1
  • prohormone convertase 1
  • prohormone convertase 3
  • furin homolog
  • prohormone convertase 1/3
  • propeptide-processing protease
  • proprotein convertase 1
  • Protein convertase subtilisin / kexin type I
  • Protein convertase subtilisin / kexin, type I
  • prohormone convertase
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