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PDE8A Produits

(phosphodiesterase 8A (PDE8A))

Catégories

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011].

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Catégories PDE8A en vedette

PDE8A Anticorps

High quality antibodies with extensive validation data.

PDE8A Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PDE8A recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (3)
N° du produit ABIN518727
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
N° du produit ABIN7155164
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (2)
N° du produit ABIN1690735
Quantité 0.1 mg
Fiche technique Fiche technique

PDE8A recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6232261
Quantité 96 tests
Fiche technique Fiche technique

PDE8A recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1314488
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1314490
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3094410
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits PDE8A

Maréchal, Guillemette, Goupil, Blondin, Leclerc, Richard: "Cyclic nucleotide phosphodiesterases in human spermatozoa and seminal fluid: Presence of an active PDE10A in human spermatozoa." dans: Biochimica et biophysica acta, Vol. 1861, Issue 2, pp. 147-156, (2017) (PubMed).

Petersen, Kristensen, Jeppesen, Grøndahl, Wissing, Macklon, Andersen: "Distribution and function of 3',5'-Cyclic-AMP phosphodiesterases in the human ovary." dans: Molecular and cellular endocrinology, Vol. 403, pp. 10-20, (2015) (PubMed).

Kelly, Adamowicz, Bove, Hartman, Mariga, Pathak, Reinhart, Romegialli, Kleiman: "Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain." dans: Cellular signalling, Vol. 26, Issue 2, pp. 383-97, (2014) (PubMed).

Vang, Housley, Dong, Basole, Ben-Sasson, Kream, Epstein, Clark, Brocke: "Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac." dans: The Biochemical journal, Vol. 456, Issue 3, pp. 463-73, (2013) (PubMed).

Kruse, Møller, Kruuse: "Distribution of PDE8A in the nervous system of the Sprague-Dawley rat." dans: Journal of chemical neuroanatomy, Vol. 42, Issue 3, pp. 184-91, (2012) (PubMed).

Bol, Booiman, Bunnik, Moerland, van Dort, Strauss, Sieberer, Schuitemaker, Kootstra, van t Wout: "Polymorphism in HIV-1 dependency factor PDE8A affects mRNA level and HIV-1 replication in primary macrophages." dans: Virology, Vol. 420, Issue 1, pp. 32-42, (2011) (PubMed).

Wu, Wang: "Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 51, pp. 17634-9, (2004) (PubMed).

Gamanuma, Yuasa, Sasaki, Sakurai, Kotera, Omori: "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans." dans: Cellular signalling, Vol. 15, Issue 6, pp. 565-74, (2003) (PubMed).

Shahan, Sorenson, Simpson, Kefalides, Lewis: "Tyrosine kinase activation in response to fungal spores is primarily dependent on endogenous reactive oxygen production in macrophages." dans: The Journal of biological chemistry, Vol. 275, Issue 14, pp. 10175-81, (2000) (PubMed).

Yang, Malek, Desiderio: "An SH3-binding site conserved in Bruton's tyrosine kinase and related tyrosine kinases mediates specific protein interactions in vitro and in vivo." dans: The Journal of biological chemistry, Vol. 270, Issue 35, pp. 20832-40, (1995) (PubMed).

Synonymes et noms alternatifs relatifs à PDE8A

phosphodiesterase 8A (PDE8A), phosphodiesterase 8A (Pde8a), phosphodiesterase 8A (pde8a), AI551852, HsT19550, Pde8, PDE8A, Pde8a, RNPDE8A

Protein level used designations for PDE8A

  • phosphodiesterase 8A
  • high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
  • phosphodiesterase 8a
  • high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A-like
  • cAMP-specific cyclic nucleotide phosphodiesterase 8A
  • mmPDE8
  • cAMP-specific cyclic nucleotide phosphodiesterase PDE8
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