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PDP Produits

(Pyruvate Dehydrogenase Phosphatase (PDP))
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported\; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009].

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Catégories PDP en vedette

PDP Anticorps

High quality antibodies with extensive validation data.

PDP Kits ELISA

Reliable ELISA kits for a wide range of species.

PDP Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PDP recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Rat
Application WB, IHC (p)
Validations
  • (1)
  • (3)
N° du produit ABIN656386
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IF
Validations
  • (4)
N° du produit ABIN6145404
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application IHC
Validations
  • (3)
N° du produit ABIN7262136
Quantité 200 μL
Fiche technique Fiche technique

PDP recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6969803
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6959011
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN1116879
Quantité 96 tests
Fiche technique Fiche technique

PDP recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7392629
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7392626
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN3011412
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits PDP

Golias, Papandreou, Sun, Kumar, Brown, Swanson, Pai, Jaitin, Le, Teknos, Denko: "Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours." dans: Scientific reports, Vol. 6, pp. 31146, (2016) (PubMed).

Shan, Kang, Elf, Xie, Gu, Aguiar, Lonning, Hitosugi, Chung, Arellano, Khoury, Shin, Khuri, Boggon, Fan: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." dans: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).

Synonymes et noms alternatifs relatifs à PDP

Pyruvate dehydrogenase phosphatase (Pdp), pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial (LOC413080), pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (Pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog (pdp1.L), 153332_at, CG12151, Dmel\\CG12151, Gm1024, im:7157162, PDH, PDP, pdp, pdp1, PDPC, PPM2C, Ppm2c, ppm2c, zgc:174908

Protein level used designations for PDP

  • CG12151-PA
  • CG12151-PB
  • Pdp-PA
  • Pdp-PB
  • pyruvate dehydrogenase phosphatase
  • PDP 1
  • PDPC 1
  • [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
  • protein phosphatase 2C, magnesium-dependent, catalytic subunit
  • pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase
  • pyruvate dehydrogenase phosphatase catalytic subunit 1
  • protein phosphatase 2C, magnesium dependent, catalytic subunit
  • pyruvate dehydrogenase phosphatase isoenzyme 2
  • pyruvate dehydrogenase phosphatase isoenzyme 1
  • pyruvate dehydrogenase phosphatase, catalytic subunit 1
  • pyruvate dehyrogenase phosphatase catalytic subunit 1
  • pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog
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