PDP Produits
(Pyruvate Dehydrogenase Phosphatase (PDP))
Catégories
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported\; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009].
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Catégories PDP en vedette
PDP Anticorps
High quality antibodies with extensive validation data.
PDP Kits ELISA
Reliable ELISA kits for a wide range of species.
PDP Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PDP recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Rat
Application
WB, IHC (p)
Validations
- (1)
- (3)
N° du produit
ABIN656386
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (4)
N° du produit
ABIN6145404
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (3)
N° du produit
ABIN7262136
Quantité
200 μL
Fiche technique
Fiche technique
PDP recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6969803
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6959011
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN1116879
Quantité
96 tests
Fiche technique
Fiche technique
PDP recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7578742
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7392629
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7392626
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits PDP
: "Hypoxic repression of pyruvate dehydrogenase activity is necessary for metabolic reprogramming and growth of model tumours." dans: Scientific reports, Vol. 6, pp. 31146, (2016) (PubMed).: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." dans: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à PDP
Pyruvate dehydrogenase phosphatase (Pdp), pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial (LOC413080), pyruvate dehyrogenase phosphatase catalytic subunit 1 (PDP1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (Pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 (pdp1), pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog (pdp1.L), 153332_at, CG12151, Dmel\\CG12151, Gm1024, im:7157162, PDH, PDP, pdp, pdp1, PDPC, PPM2C, Ppm2c, ppm2c, zgc:174908Protein level used designations for PDP
- CG12151-PA
- CG12151-PB
- Pdp-PA
- Pdp-PB
- pyruvate dehydrogenase phosphatase
- PDP 1
- PDPC 1
- [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial
- protein phosphatase 2C, magnesium-dependent, catalytic subunit
- pyruvate dehydrogenase (Lipoamide) phosphatase-phosphatase
- pyruvate dehydrogenase phosphatase catalytic subunit 1
- protein phosphatase 2C, magnesium dependent, catalytic subunit
- pyruvate dehydrogenase phosphatase isoenzyme 2
- pyruvate dehydrogenase phosphatase isoenzyme 1
- pyruvate dehydrogenase phosphatase, catalytic subunit 1
- pyruvate dehyrogenase phosphatase catalytic subunit 1
- pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog
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