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PEN2 Produits

(Presenilin Enhancer 2 Homolog (PSENEN))
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase. [provided by RefSeq, Jul 2008].

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Catégories PEN2 en vedette

PEN2 Anticorps

High quality antibodies with extensive validation data.

PEN2 Kits ELISA

Reliable ELISA kits for a wide range of species.

PEN2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

PEN2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Mouse, Rat
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
  • (2)
N° du produit ABIN1387540
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
N° du produit ABIN7139851
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA
Validations
  • (2)
N° du produit ABIN565943
Quantité 100 μg
Fiche technique Fiche technique

PEN2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6231793
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Cow
Analytical Method
Validations
N° du produit ABIN2870254
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Competition ELISA
Validations
N° du produit ABIN6200572
Quantité 96 tests
Fiche technique Fiche technique

PEN2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1316522
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3107691
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3128357
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits PEN2

Chu, Peng, Long, Wang, Luo, Sharma, He: "Distribution and expression of Pen-2 in the central nervous system of APP/PS1 double transgenic mice." dans: Acta biochimica et biophysica Sinica, Vol. 47, Issue 4, pp. 258-66, (2015) (PubMed).

Periz, Fortini: "Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2." dans: Journal of neuroscience research, Vol. 77, Issue 3, pp. 309-22, (2004) (PubMed).

Luo, Wang, Li, Kim, Shah, Lee, Thinakaran, Kim, Yu, Xu: "PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1." dans: The Journal of biological chemistry, Vol. 278, Issue 10, pp. 7850-4, (2003) (PubMed).

Crystal, Morais, Pierson, Pijak, Carlin, Lee, Doms: "Membrane topology of gamma-secretase component PEN-2." dans: The Journal of biological chemistry, Vol. 278, Issue 22, pp. 20117-23, (2003) (PubMed).

Takasugi, Tomita, Hayashi, Tsuruoka, Niimura, Takahashi, Thinakaran, Iwatsubo: "The role of presenilin cofactors in the gamma-secretase complex." dans: Nature, Vol. 422, Issue 6930, pp. 438-41, (2003) (PubMed).

Marlow, Canet, Haugabook, Hardy, Lahiri, Sambamurti: "APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity." dans: Biochemical and biophysical research communications, Vol. 305, Issue 3, pp. 502-9, (2003) (PubMed).

Francis, McGrath, Zhang, Ruddy, Sym, Apfeld, Nicoll, Maxwell, Hai, Ellis, Parks, Xu, Li, Gurney, Myers, Himes, Hiebsch, Ruble, Nye, Curtis: "aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation." dans: Developmental cell, Vol. 3, Issue 1, pp. 85-97, (2002) (PubMed).

Synonymes et noms alternatifs relatifs à PEN2

presenilin enhancer gamma-secretase subunit (PSENEN), presenilin enhancer 2 (PEN2), presenilin enhancer 2 (Psenen), presenilin enhancer gamma secretase subunit (Psenen), Gamma-secretase subunit pen-2 (pen-2), presenilin enhancer (pen-2), presenilin enhancer gamma secretase subunit S homeolog (psenen.S), presenilin enhancer gamma secretase subunit (psenen), presenilin enhancer gamma-secretase subunit (Psenen), 1700023M09Rik, ACYPI006208, anon-AE003800.1, CG33198, Dmel\\CG33198, dPen-2, MSTP064, PEN-2, Pen-2, pen-2, PEN2, pen2, Psenen, psenen, RGD1312037, zgc:109727

Protein level used designations for PEN2

  • gamma-secretase subunit PEN-2
  • hematopoietic stem/progenitor cells protein MDS033
  • presenilin enhancer protein 2
  • presenilin enhancer 2
  • LRRGT00140 mRNA
  • liver regeneration-related protein LRRGT00140
  • CG33198-PA
  • pen-2-PA
  • presenilin enhancer 2 homolog
  • presenilin enhancer gamma secretase subunit S homeolog
  • Presenilin enhancer protein 2 homolog
  • presenilin enhancer protein 2 homolog
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