PEX5 Produits
(Peroxisomal Biogenesis Factor 5 (PEX5))
Catégories
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].
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Catégories PEX5 en vedette
PEX5 Anticorps
High quality antibodies with extensive validation data.
PEX5 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
PEX5 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
N° du produit
ABIN6145469
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
IHC, IF
Validations
- (4)
N° du produit
ABIN7261734
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Dog, Human, Monkey, Rat
Application
WB, IF, FACS
Validations
- (4)
N° du produit
ABIN1500156
Quantité
100 μL
Fiche technique
Fiche technique
PEX5 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6233831
Quantité
96 tests
Fiche technique
Fiche technique
PEX5 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7124372
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1314707
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3131369
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits PEX5
: "Carboxy-terminal mutations of bile acid CoA:N-acyltransferase alter activity and substrate specificity." dans: Journal of lipid research, Vol. 57, Issue 7, pp. 1133-43, (2016) (PubMed).: "A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS." dans: Nature cell biology, Vol. 15, Issue 10, pp. 1186-96, (2013) (PubMed).
: "Mapping the cargo protein membrane translocation step into the PEX5 cycling pathway." dans: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27243-51, (2009) (PubMed).
: "Mitochondrial alterations caused by defective peroxisomal biogenesis in a mouse model for Zellweger syndrome (PEX5 knockout mouse)." dans: The American journal of pathology, Vol. 159, Issue 4, pp. 1477-94, (2001) (PubMed).
: "PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import." dans: The Journal of cell biology, Vol. 147, Issue 4, pp. 761-74, (1999) (PubMed).
: "Recombinant human peroxisomal targeting signal receptor PEX5. Structural basis for interaction of PEX5 with PEX14." dans: The Journal of biological chemistry, Vol. 274, Issue 9, pp. 5666-73, (1999) (PubMed).
: "A mouse model for Zellweger syndrome." dans: Nature genetics, Vol. 17, Issue 1, pp. 49-57, (1997) (PubMed).
Synonymes et noms alternatifs relatifs à PEX5
peroxisomal biogenesis factor 5 (pex5), peroxisomal biogenesis factor 5 (Pex5), peroxisomal biogenesis factor 5 (PEX5), AW212715, ESTM1, PBD2A, PBD2B, Peroxin-5, PTS1-BP, PTS1R, Pxr1, PXR1, X83306Protein level used designations for PEX5
- peroxisome biogenesis factor 5
- PTS1 receptor
- PTS1-BP
- PXR1P
- peroxin 5
- peroxisomal C-terminal targeting signal import receptor
- peroxisomal targeting signal 1 receptor
- peroxisome receptor 1
- peroxin-5
- peroxisomal targeting signal 1 (SKL type) receptor
- peroxisomal targeting signal import receptor
- peroxisomal targeting signal receptor 1
- PTS1R
- Peroxisomal C-terminal targeting signal import receptor
- Peroxisome receptor 1
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